Induction of pluripotent stem cells from adult somatic cells by protein ...

The concept of reprogramming of somatic cells has opened a new era in regenerative medicine. Transduction of defined factors has ...

Induction of pluripotent stem cells from adult human fibroblasts by ...

Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and ...

We report that that a single transfer of embryonic stem (ES) cell-derived proteins into primarily cultured adult mouse fibroblasts, rather than repeated ...

Induced pluripotent stem cells (iPSCs): molecular mechanisms of ...

iPSCs have the capacity for an almost unlimited expansion, are amenable to genetic engineering, and can be differentiated into most somatic cell ...

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by ...

Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells.

Turning Somatic Cells into Pluripotent Stem Cells - Nature

The reprogrammed cells, called induced pluripotent stem (iPS) cells, exhibit functional similarities to ES cells and present an exciting area of research.

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by ...

Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and ...

Generation of Human Induced Pluripotent Stem Cells by Direct ...

Here we report the generation of stable iPSCs from human fibroblasts by directly delivering four reprogramming proteins (Oct4, Sox2, Klf4, and c-Myc) fused with ...

Human Induced Pluripotent Stem Cells: From Cell Origin, Genomic ...

On the other hand, reprogramming of somatic cells to iPSCs requires profound modifications in the epigenetic landscape. Changes in chromatin structure by DNA ...

Induced pluripotent stem cell - Wikipedia

Since iPSCs can be derived directly from adult tissues, they not only bypass the need for embryos, but can be made in a patient-matched manner, which means that ...

Induction of pluripotent stem cells from adult somatic cells by protein ...

Induction of pluripotent stem cells from adult somatic cells by protein-based reprogramming without genetic manipulation Check holdings Library Depot Off ...

Derivation of induced pluripotent stem cells from pig somatic cells

Here, we describe induced pluripotent stem cells (iPSC) derived from porcine fetal fibroblasts by lentiviral transduction of 4 human (h) genes, hOCT4, hSOX2, ...

Stem cells: past, present, and future

The pluripotency of stem cells allows them to form any cell of the organism. Human embryonic stem cells (hESCs) are derived from the ICM. During ...

Advances in Pluripotent Stem Cells: History, Mechanisms ...

This is because iPSCs are derived from adult somatic tissues, and hiPSC sources, such as blood, skin, and urine, are plentiful. In addition, ...

The occurrence and development of induced pluripotent stem cells

The cultivation conditions for iPSCs also play an indispensable role in reprogramming. For the cultivation of human pluripotent stem cells, both feeder-free (Ff) ...

Induced Pluripotent Stem Cell Experiments by Kazutoshi Takahashi ...

They called the pluripotent stem cells that they produced induced pluripotent stem cells (iPSCs) because they had induced the adult cells, ...

Inducing somatic cells into pluripotent stem cells is an important ...

Induced pluripotent stem cells (iPSCs), a nonclonal technique to produce stem cells, are originated from differentiated somatic cells via ...

Progress in the Reprogramming of Somatic Cells - AHA Journals

Pluripotent stem cells can self-renew indefinitely and undergo differentiation to produce all types of cells in adult bodies.

Differentiation Potential of Induced Pluripotent Stem Cells

Induced pluripotent stem cells (iPS cells) are generated by reprogramming adult somatic cells. Following isolation, somatic cells are cultured in vitro and ...

Reprogramming of murine and human somatic cells using a single ...

In addition we have generated human induced pluripotent stem (hiPS) cell lines from human keratinocytes, demonstrating that a single ...