- Inherited lung cancer syndromes targeting never smokers🔍
- Hereditary Lung Cancer Syndrome Targets Never Smokers with ...🔍
- Germline EGFR Mutations and Familial Lung Cancer🔍
- Inherited lung cancer🔍
- Familial rare EGFR|mutant lung cancer syndrome🔍
- First Prospective Description of Familial EGFR|mutated Lung Cancer🔍
- Lung cancer in never|smokers🔍
- Lung Cancer in Nonsmokers🔍
Inherited lung cancer syndromes targeting never smokers
Inherited lung cancer syndromes targeting never smokers - PubMed
Lung cancer is the leading cause of cancer death worldwide. Most of lung cancers develop sporadically and thus inherited lung cancers are rare.
Inherited lung cancer syndromes targeting never smokers - Yamamoto
Germline EGFR T790M mutations cause rare and characteristic inherited lung cancer syndromes, which target female never smokers. Although only one pedigree is so ...
Hereditary Lung Cancer Syndrome Targets Never Smokers with ...
Introduction: Hereditary lung cancer syndromes are rare, and T790M germline mutations of the epidermal growth factor receptor (EGFR) gene predispose to the ...
Germline EGFR Mutations and Familial Lung Cancer
Such targetable mutations are detected more commonly in NSCLC occurring in patients with no history of cigarette smoking. Lung cancer in never ...
Inherited lung cancer: a review - ecancer
Among these, T790M seems to be associated with a specific lung cancer syndrome targeting never-smokers [48]. In various studies, Sanger ...
Familial rare EGFR-mutant lung cancer syndrome - ScienceDirect.com
R776H EGFR lung cancer mutations are over-represented in light or never smoking female patients who often also possess an additional somatic EGFR mutation.
First Prospective Description of Familial EGFR-mutated Lung Cancer
Such targetable mutations are detected more commonly in NSCLC occurring in patients with no history of cigarette smoking. However, understanding ...
Lung cancer in never-smokers | European Respiratory Society
EGFR mutations, ALK rearrangements and KRAS mutations were the three most frequently identified and clinically relevant genetic alterations in NSCLC in never- ...
Lung Cancer in Nonsmokers - Yale Medicine
Smokers and non/never-smokers tend to develop different types of lung cancer; the latter group is more likely to develop lung cancer as a result of a genetic ...
Lung cancer in nonsmokers: The latest research
30% of NSCLC cases are driven by genetic mutations that are treatable with targeted therapies. Lung cancers found in never-smokers are more ...
Lung cancer in never smokers—the East Asian experience - Zhou
Therefore, targeted therapy inhibiting oncogenic mutant kinases plays a pivotal role for the treatment of lung adenocarcinoma in never-smoking East Asians.
EGF receptor gene mutations are common in lung cancers from ...
Collectively, these data show that adenocarcinomas from never smokers comprise a distinct subset of lung cancers, frequently containing ...
Mutational Characteristics and Clinical Outcomes for Lung ...
NSCLC driven by EGFR germline mutations occurs more often in white, non-smoking women, and is associated with a strong family history of lung cancer. It is also ...
Germline EGFR mutations in lung cancer (Review)
Furthermore, T790M has been linked to familial non-small cell lung cancer (NSCLC) (7) and in a population of never-smoking women who carry the ...
Germline ERBB3 mutation in familial non-small-cell lung carcinoma
Rarely, dominantly inherited non-small-cell lung cancer (NSCLC) has been reported due to somatic mutations in EGFR/ErbB1 and ERBB2. Germline exome sequencing ...
Hereditary Lung Cancer Syndrome Targets Never Smokers ... - OUCI
Hereditary Lung Cancer Syndrome Targets Never Smokers with Germline EGFR Gene T790M Mutations · Adi Gazdar · Linda Robinson · Dwight Oliver · Chao Xing · William D.
Potential genetic modifiers for somatic EGFR mutation in lung cancer
Accumulating evidence indicates inherited risk in the aetiology of lung cancer, although smoking exposure is the major attributing factor.
Genomic Evolution in a Patient With Lung Adenocarcinoma With a ...
∙ Yatabe, Y. ∙ Toyooka, S. Inherited lung cancer syndromes targeting never smokers. Transl Lung Cancer Res. 2018; 7:498-504.
Mutational Characteristics and Clinical Outcomes for Lung ...
∙ Yatabe, Y. ∙ Toyooka, S. Inherited lung cancer syndromes targeting never smokers. Transl Lung Cancer Res. 2018; 7:498-504.
Genetic differences between smokers and never-smokers with lung ...
Both the number of cigarettes per day (expressed in packyears) and duration of smoking influence lung cancer risk, even after smoking cessation. Almost all ...