Inhibition of endoplasmic reticulum

Inhibition of endoplasmic reticulum (ER) stress sensors sensitizes ...

The combination of cisplatin and an IRE1α inhibitor had a synergistic effect on ER stress-mediated apoptosis. Our results demonstrated that the inhibition of ER ...

Pharmacological inhibition of endoplasmic reticulum stress mitigates ...

Hindlimb suspension (HLS) mice exhibit osteoporosis of the hindlimb bones and may be an excellent model to test pharmacological ...

Inhibition of Endoplasmic Reticulum-associated Degradation ...

Background: Lysosomal storage disorders are caused by ER-associated degradation (ERAD) of mutated unstable lysosomal enzymes. Results: ERAD inhibition ...

Endoplasmic reticulum stress: molecular mechanism and ... - Nature

Therefore, inhibition of PTM results in protein accumulation and ER stress in TM cells, which causes TM cell loss and ECM accumulation.

Chemical Chaperones to inhibit Endoplasmic reticulum stress | DDDT

In this review, synthetic or semi-synthetic chemical chaperones are categorized according to potential therapeutic area and listed along with their chemical ...

Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation ...

Our research demonstrated that simultaneous inhibition of ER stress and oxidative stress could effectively repolarize M2-TAMs under hypoxia.

Covalent inhibition of endoplasmic reticulum chaperone GRP78 ...

Celastrol covalently inhibited the chaperone activity of GRP78 and could disconnect the transduction of ER stress signal to downstream ...

Abstract TMP116: Pharmacological Inhibition Of Endoplasmic ...

Background: The endoplasmic reticulum (ER) is responsible for cellular protein synthesis and folding. Cellular stimuli that perturb ER ...

Inhibition of endoplasmic-reticulum-stress-mediated autophagy ...

Conclusions. Sunitinib combined with chloroquine reduces tumor growth through suppression of autophagy and increased apoptosis. Co- ...

Inhibition of Endoplasmic Reticulum Associated Degradation ...

Impairment of ERAD results in decreased UPR activation and protects against ER stress toxicity. Autophagy induction is not affected under these conditions.

A pipeline for natural small molecule inhibitors of endoplasmic ...

The endoplasmic reticulum (ER) plays a substantial role in the upkeep of the proteostasis of any eukaryotic cell. Upon unresolved ER stress, ...

Inhibition of endoplasmic reticulum stress ameliorates ...

The present study provided evidence that the inhibition of ER stress by TUDCA ameliorated cardiovascular complications in a rat model of Met syndrome through a ...

Inhibition of endoplasmic reticulum-to-Golgi traffic by poliovirus ...

Abstract. Poliovirus protein 3A, only 87 amino acids in length, is a potent inhibitor of protein secretion in mammalian cells, blocking ...

Inhibition of Endoplasmic Reticulum Calcium Channels Reduces ...

Conclusions : We show that the inhibition of the ER calcium channels reduces ER stress and cone death, supporting the view that ER calcium depletion/cytosolic ...

A Pipeline for Natural Small Molecule Inhibitors of Endoplasmic ...

The endoplasmic reticulum (ER) plays a substantial role in the upkeep of the proteostasis of any eukaryotic cell. Upon unresolved ER stress, several stress ...

Inhibition of Endoplasmic Reticulum Stress Improves Mouse Embryo ...

Effects of Culture Stress on Mouse Preimplantation Embryo Development in vitro. Tunicamycin (TM), a compound that inhibits N-linked glycosylation in newly ...

Inhibition of endoplasmic reticulum stress alleviates cigarette smoke ...

Our results suggest that ER stress is crucial for CS-induced inflammation and emphysema, and that targeting ER stress may represent a novel approach to the ...

Inhibition of endoplasmic reticulum (ER)-to-Golgi transport induces ...

Inhibition of endoplasmic reticulum (ER)-to-Golgi transport induces relocalization of binding protein (BiP) within the ER to form the BiP bodies ...

Inhibition of endoplasmic reticulum stress and the downstream ...

Our findings indicate that ER stress inhibitors may play a protective role by reducing CD4+ T cell apoptosis and maintaining CD4+ T cell ...

Inhibition of the endoplasmic reticulum stress‐associated IRE‐1 ...

Studies have shown that ERS can drive autophagy by converting LC3-I into LC3-II, especially in embryonic fibroblasts. Furthermore, acupuncture ...