- Inhibition of protein translocation at the endoplasmic reticulum ...🔍
- Inhibitors of Protein Translocation Across the ER Membrane🔍
- Inhibition of Protein Translocation across the Endoplasmic ...🔍
- A substrate|specific inhibitor of protein translocation into the ...🔍
- Eeyarestatin I inhibits Sec61|mediated protein translocation at the ...🔍
- Inhibitors of protein translocation across membranes of the secretory ...🔍
- Protein translocation and retro|translocation across the endoplasmic ...🔍
- [PDF] Inhibition of protein translocation at the endoplasmic reticulum ...🔍
Inhibition of protein translocation at the endoplasmic reticulum ...
Inhibition of protein translocation at the endoplasmic reticulum ...
ESI inhibits translocation of proteins across the ER membrane, leading to the production of non-translocated proteins (NTP) at the cytosolic face of the ER ...
Inhibition of protein translocation at the endoplasmic reticulum ...
Selective small-molecule inhibitors represent powerful tools for the dissection of complex biological processes. ES(I) (eeyarestatin I) is a ...
Inhibitors of Protein Translocation Across the ER Membrane
Inhibitors of protein transport into the ER can target virtually any stage: they can interfere with keeping proteins translocation competent like the Hsp70 ...
Inhibition of Protein Translocation across the Endoplasmic ...
Inhibition of Protein Translocation across the Endoplasmic Reticulum Membrane by Sterols*. IngMarie Nilsson. IngMarie Nilsson. Affiliations. Department of ...
A substrate-specific inhibitor of protein translocation into the ... - Nature
Here we describe cotransin, a small molecule that inhibits protein translocation into the endoplasmic reticulum. Cotransin acts in a signal- ...
Inhibition of protein translocation at the endoplasmic reticulum ...
Unexpectedly, our results suggest that these non-translocated polypeptides promote activation of the UPR (unfolded protein response), and indeed we can ...
(PDF) Inhibition of protein translocation at the endoplasmic reticulum ...
Unexpectedly, our results suggest that these non-translocated polypeptides promote activation of the UPR (unfolded protein response), and indeed ...
Eeyarestatin I inhibits Sec61-mediated protein translocation at the ...
We have characterised this inhibition of ER translocation both in vivo and in vitro, and provide evidence that ESI targets a component of the ...
Inhibitors of protein translocation across membranes of the secretory ...
The Sec61/SecY translocon forms a passive pore in the ER membrane (or plasma membrane in bacteria) where the targeting signal needs to be ...
Protein translocation and retro-translocation across the endoplasmic ...
Secretory and transmembrane proteins are shuttled into the ER via the Sec61 translocon, where they undergo appropriate folding; misfolded proteins are retro- ...
Inhibition of Protein Translocation across the Endoplasmic ...
Our data suggest that the protein trans- location machinery may be sensitive to changes in cholesterol levels in the ER membrane. Sterols are ...
[PDF] Inhibition of protein translocation at the endoplasmic reticulum ...
The results suggest that the accumulation of non-translocated proteins in the cytosol may represent a novel mechanism that contributes to UPR activation, ...
Regulation of Translation, Translocation, and Degradation of ... - MDPI
The endoplasmic reticulum (ER) of mammalian cells is the central organelle for the maturation and folding of transmembrane proteins and for proteins ...
Eeyarestatin Compounds Selectively Enhance Sec61-Mediated ...
Chemical modulators that inhibit protein translocation at the level of Sec61 complexes may, therefore, have an impact on ER Ca2+ leakage. Combining biochemical ...
Inhibition of protein translocation across the endoplasmic reticulum ...
Here, we report that an early step in protein translocation across the endoplasmic reticulum (ER) membrane is reversibly inhibited by cholesterol levels ...
Inhibitors of the Sec61 Complex and Novel High Throughput ... - MDPI
A central component in this protein translocation process across the ER is the Sec61 translocon complex, which is only intracellularly expressed and does not ...
Signal Peptide-Binding Drug as a Selective Inhibitor of Co ... - PLOS
The cell uses an elegant way to discriminate proteins that need to be translocated into the ER from those that have to reside in the cytosol by scanning for the ...
Inhibitors of Protein Translocation Across the ER Membrane - Kalies
Traffic is a cell biology and biochemistry journal devoted to intracellular transport, covering subcellular trafficking, membrane dynamics, ...
"Inhibition of protein translocation at the endoplasmic reticulum ...
Unexpectedly, our results suggest that these non-translocated polypeptides promote activation of the UPR (unfolded protein response), and indeed we can ...
Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation
lanes 1, 3, and 4), both events specific to the ER lumen. The unusual ability of tail-anchored membrane proteins to insert into the ER membrane ...