Innate Immunity in the Pathogenesis of Glomerular Disease

Role of the Innate Immune Response in Glomerular Disease ...

Role of the Innate Immune Response in Glomerular Disease Pathogenesis: Focus on Podocytes ... Cells. 2024 Jul 6;13(13):1157. doi: 10.3390/cells13131157.

Recent studies identify innate immunity as a key player in glomerular disease pathogenesis, and that this involves various immunomodulatory mechanisms.

Role of the Innate Immune Response in Glomerular Disease ... - MDPI

Podocytes, the terminally differentiated epithelial cells, are crucial for maintaining the integrity of the glomerular filtration barrier. Once injured, ...

The Emerging Role of Innate Immunity in Chronic Kidney Diseases

Leukocyte infiltration plays a pivotal role in the pathogenesis of renal fibrosis. Upon injury, infiltrated leukocytes secret pro-inflammatory cytokines to ...

Glomerulonephritis: immunopathogenesis and immunotherapy

Glomerular injury in immune complex GN occurs upon activation of Fc receptors on resident cells or infiltrating immune cells, as well as upon ...

Unraveling the immunopathogenesis of glomerular disease

Immune-mediated damage to the glomerulus drives the pathogenesis of glomerular diseases. · Both innate and adaptive immune cells and their mediators contribute ...

Role of the Innate Immune Response in Glomerular Disease ...

... immunity mechanisms involved in podocyte injury and the ... Role of the Innate Immune Response in Glomerular Disease Pathogenesis: Focus on Podocytes.

The podocyte: glomerular sentinel at the crossroads of innate and ...

Beyond its role in innate immunity, the podocyte is capable of contributing to the adaptive immune response (16). The podocyte has been shown to possess ...

Mechanisms of immune injury of the glomerulus - UpToDate

RELATED TOPICS · Anti-GBM (Goodpasture) disease: Pathogenesis, clinical manifestations, and diagnosis · Antiphospholipid syndrome and the kidney ...

(PDF) Role of the Innate Immune Response in Glomerular Disease ...

Contribution of the innate immune system to glomerular disease pathogenesis. Current knowledge suggests that many molecules of innate immunity ...

New insights into mechanisms of immune-mediated glomerular ...

There are dozens of different immune-mediated glomerular diseases. For the purpose of this review we will focus on two examples in which the clinical pathology ...

Advances in Understanding of Pathogenesis and Treatment of ...

In direct immune-mediated kidney diseases, specific antigens within the kidney are targets of an immune response. Differences in their ...

Contribution of the innate immune system to glomerular disease...

Download scientific diagram | Contribution of the innate immune system to glomerular disease pathogenesis. Current knowledge suggests that many molecules of ...

Immune abnormalities in IgA nephropathy | Clinical Kidney Journal

Therefore, activation of TLRs by infections may exacerbate IgAN by activating cells of the innate immune system that, in turn, affect glomerular ...

Mechanisms of Glomerular Disease - SpringerLink

The immune response, which can be broadly divided into the innate and adaptive immune systems, is a major contributor to the pathogenesis of ...

Editorial: Pathogenic aspects of the innate immune system of the ...

First, all three original articles are related to the roles of Mφ in various renal diseases. Mφ is one of the major phagocytic cell components of innate immune ...

Immunology of Kidney Disease - Annual Reviews

The kidneys' innate immune system serves as the initial line of pro- tection. Renal-resident cells such as macrophages, DCs, and NK cells are ...

Innate immunity in diabetic kidney disease - Nature

Immune cells and resident renal cells that activate innate immunity have critical roles in triggering and sustaining inflammation in this ...

five types of glomerulonephritis classified by pathogenesis, activity ...

Indeed, altered systemic immunity is the primary pathogenic process and the key therapeutic target in GN. Here, we apply a conceptual framework ...

The innate immune system in human kidney inflammaging

TLR upregulation leads to proinflammatory cytokine induction, fibrosis, and chronic kidney disease progression. TLR2 blockade in a murine model ...