Innate immunity and the failing heart

Innate Immunity and the Failing Heart | Circulation Research

Studies have shown that the ensuing inflammatory response induced by the innate immune system can be physiological and result in the ...

Innate immunity and the failing heart: the cytokine hypothesis revisited

Elevated levels of inflammatory mediators have been identified in patients with heart failure, including heart failure with reduced and ...

THE EMERGING ROLE OF INNATE IMMUNITY IN THE HEART AND ...

Recent studies suggest that the heart possesses an innate immune system that is intended to delimit tissue injury, as well as orchestrate homoeostatic ...

Therapeutic targeting of innate immunity in the failing heart

▻Long-term TLR signaling is maladaptive and may lead to cardiac remodeling. ▻Innate immune genes are differentially expressed in non-failing and failing hearts.

Heart failure affects innate immune memory - Nature

A study by Nakayama et al. shows that heart failure causes epigenetic changes in haematopoietic stem cells that predispose to further heart ...

Activation of the innate immune system in the pathogenesis of acute ...

Although experimental evidence suggests that activation of inflammatory and immune responses may contribute to the pathogenesis of chronic heart failure, ...

Association of innate versus specific immunity with heart failure ...

Neutrophils, monocytes, SII (systemic immune-inflammatory index), NLR (neutrophil-to-lymphocyte ratio), and PLR (platelet-to-lymphocyte ratio) serve as innate ...

Immunity, Inflammation and Heart Failure: Their Role on Cardiac ...

Aims: Heart failure is a clinical syndrome characterized by subclinical systemic inflammation and immune system activation associated with iron deficiency. No ...

Heart failure promotes multimorbidity through innate immune memory

These finding demonstrate that the bone marrow can carry an innate immune memory of cardiac stress that may exacerbate HF and predispose other organs to ...

The innate immune system in chronic cardiomyopathy: a European ...

Activation of the immune system in heart failure (HF) has been recognized for over 20 years. Initially, experimental studies demonstrated a ...

Innate immune response in the pathogenesis of heart failure in ...

This second phase of an increase in OS, innate inflammatory response, and apoptosis results in wall thinning, dilatation, and consequently HF.

Innate immunity and remodelling | Heart Failure Reviews

Since then, a large number of publications have documented the activation of the innate immune system in heart failure patients. Patients with ...

Dendritic cell–induced autoimmune heart failure requires ... - Nature

Here we provide the first in vivo evidence that the concerted action of innate and adaptive immunity on DCs triggers autoimmune heart disease, relapses and ...

Immune mechanisms in heart failure - Wiley Online Library

Experimental studies have shown activation of immune response mechanisms in the heart to provoke cardiac adverse remodelling and cause left ...

Innate Immunity and the Failing Heart: The Cytokine Hypothesis ...

Elevated levels of inflammatory mediators have been identified in patients with heart failure, including heart failure with reduced and preserved ejection ...

Innate Immunity and the Failing Heart - OUCI

Elevated levels of inflammatory mediators have been identified in patients with heart failure, including heart failure with reduced and preserved ejection ...

Role of Innate Immunity in Heart Failure - Thoracic Key

Outline Overview of Innate Immunity, 103 Expression and Regulation of Pattern Recognition Receptors in the Heart, 103 Toll Receptors, ...

Role of Innate Immunity in Heart Failure - Clinical Tree

The literature suggests that proinflammatory cytokines serve as the downstream “effectors” of the innate immune system by facilitating tissue ...

Innate immune receptors in heart failure: Side effect or potential ...

Activated MyD88 forms a complex with IL-1R-associated protein kinases (IRAK4, IRAK1 and IRAK2) (schematic overview see Figure 1). Phosphorylation of IRAK1 leads ...

Activation of the innate immune system in the pathogenesis of acute ...

3. Miro O, Peacock FW, McMurray JJ, et al. Acute Heart Failure Study Group of the ESCACCA. European Society of Cardiology – Acute Cardiovascular Care ...