Insights into the role of derailed endocytic trafficking pathway in cancer

Here, we summarize how dysregulated endocytic trafficking process triggers tumorigenesis and progression from the perspective of several typical cancer ...

Insights into the role of derailed endocytic trafficking pathway in ...

The endocytic trafficking pathway is a highly organized cellular program responsible for the regulation of membrane components and uptake of extracellular ...

Insights into the role of derailed endocytic trafficking pathway in cancer: From the perspective of cancer hallmarks ; January 2024; Pharmacological Research 201 ...

Insights into the role of derailed endocytic trafficking pathway in cancer

Insights into the role of derailed endocytic trafficking pathway in cancer: From the perspective of cancer hallmarks ... Authors: Hongjie Guo; Chen Zhou; Mingming ...

Targeting endocytosis to sensitize cancer cells to programmed cell ...

Endocytosis, the process by which cells internalize extracellular materials, has emerged as a key regulator of cell death pathways in cancer. Many tumor types ...

Derailed endocytosis: an emerging feature of cancer

Pharmaceutical interception of the propensity of tumour cells to derail their signalling and their adhesion receptors may constitute a novel target for ...

Endocytic trafficking of connexins in cancer pathogenesis

The early endosome is the initial destination for cargo molecules internalized from the plasma membrane and is a major sorting station in the endocytic system [ ...

[PDF] Endocytosis and cancer. | Semantic Scholar

Insights into the role of derailed endocytic trafficking pathway in cancer: From the perspective of cancer hallmarks. · Medicine, Biology. Pharmacological ...

Adaptations of membrane trafficking in cancer and tumorigenesis

Cancer cells adapt membrane trafficking to enhance their survival and metabolism, and understanding these adaptations is vital for improving patient responses ...

Data driven and biophysical insights into the regulation of trafficking ...

Biomechanical signals from remodeled extracellular matrix (ECM) promote tumor progression. Here, we show that cell-matrix and cell-cell ...

Reciprocal regulation of signaling and endocytosis

However, in several TRAIL-resistant cancer cell lines, TRAIL-activated death receptors are specifically internalized by CME in a Dyn1-dependent ...

Exploring Retrograde Trafficking: Mechanisms and Consequences ...

The second route is the recycling pathway. Recycling of cargo can occur via fast recycling, direct recycling from the early endosome to the ...

Endocytosis in cancer and cancer therapy. - Abstract - Europe PMC

In the past decade, endocytosis has emerged as a pivotal regulator of nutrient scavenging, response to and regulation of immune surveillance and ...

Derailed endocytosis: an emerging feature of cancer - OUCI

... signalling and turnover. Nature Cell ... Insights into the role of derailed endocytic trafficking pathway in cancer: From the perspective of cancer hallmarks.

A Systematic Analysis Reveals Heterogeneous Changes in the ...

Endocytotic alterations in cancer cells, which affect cell surface expression patterns, have a major influence on cancer phenotypes, highlighting.

FCHSD2 controls oncogenic ERK1/2 signaling outcome by ... - PLOS

We have termed these cancer-specific changes in the endocytic machinery 'adaptive' endocytic trafficking and hypothesize that these 'gain-of- ...

FCHSD2 Controls Oncogenic ERK1/2 Signaling Outcome ... - bioRxiv

Hence, a link between endocytic trafficking and cancer progression has been suggested (Lanzetti & Di Fiore, 2008, Mellman & Yarden, 2013, ...

Role for ERK1/2-dependent activation of FCHSD2 in cancer cell ...

This study identifies signaling pathways that impinge on the endocytic machinery and reveals a molecular nexus for crosstalk between ...

Endocytosis and Sorting of ErbB2 and the Site of Action of Cancer ...

Little is known, however, about how these treatments affect ErbB2 endocytic trafficking. To investigate this issue, we examined breast carcinoma cells by ...

lncRNA HITT inhibits metastasis by attenuating Rab5-mediated ...

Endocytosis of cell surface receptors is essential for cell migration and cancer metastasis. Rab5, a small GTPase of the Rab family, ...