- Interaction analysis of subgroup effects in randomized trials🔍
- Investigating Subgroup Effects in Randomized Clinical Trials🔍
- Subgroup analyses in randomised controlled trials🔍
- Understanding of interaction 🔍
- Subgroup analyses in randomized trials🔍
- Subgroup Analysis in Randomized Controlled Trials🔍
- When to believe a subgroup analysis🔍
- Same Old Challenges in Subgroup Analysis—Should We Do More ...🔍
Interaction analysis of subgroup effects in randomized trials
Interaction analysis of subgroup effects in randomized trials - Nature
Subgroup analysis aims to identify subgroups (usually defined by baseline/demographic characteristics), who would (or not) benefit from an ...
Investigating Subgroup Effects in Randomized Clinical Trials
The interaction test essentially compares whether the treatment effect is different between, for example, males and females (ignoring the overall effect). This ...
Subgroup analyses in randomised controlled trials - PubMed
With simulated simplest case data with no differential subgroup effects, the formal tests of interaction were significant in 5% of cases as expected, while ...
Understanding of interaction (subgroup) analysis in clinical trials
In randomized clinical trials (RCTs), this type of analysis is typically referred to as subgroup analysis. Although interaction (or subgroup) analyses are ...
Interaction analysis of subgroup effects in randomized trials
Postoperative pancreatic fistula (POPF) is the most dreaded complication after distal pancreatectomy (DP). This multicenter randomized trial evaluated the ...
Understanding of interaction (subgroup) analysis in clinical trials
When the treatment effect on the outcome of interest is influenced by a baseline/demographic factor, investigators say that an interaction ...
Subgroup analyses in randomized trials: risks of subgroup-specific ...
Simulations quantified the risks of misinterpreting subgroup analyses as evidence of differential subgroup effects and the limited power of the interaction test ...
Subgroup analyses in randomized trials
Simulations quantified the risks of misinterpreting subgroup analyses as evidence of differential subgroup effects and the limited power of the interaction test ...
Subgroup Analysis in Randomized Controlled Trials - ScienceDirect
Investigators therefore often conduct analyses to explore such possible subgroup effects, also referred to as “effect modification” or “interaction”.
When to believe a subgroup analysis: revisiting the 11 criteria - Nature
The smaller the p-value of the interaction test, the stronger the subgroup effect. For instance, the CATT [14] conducted a non-inferiority trial ...
Same Old Challenges in Subgroup Analysis—Should We Do More ...
Sherry et al found that only 17% of the trials reported a P value or estimate of interaction, leaving evidence users in the dark regarding the ...
Interpretation of Subgroup Effects in Published Trials
Although the use of interaction terms is widely recommended,7,13,14 many studies reporting effect modifiers (subgroups) do not use this type of analysis.22–27 ...
Subgroup Analysis in Randomized Controlled Trials
The third question asks if the interaction test suggests that chance is an unlikely explanation for subgroup differences. The p values for ...
A systematic review of subgroup analyses in randomised clinical ...
Subgroup analyses are frequently used to assess heterogeneity of treatment effects in randomised clinical trials.
Understanding of interaction (subgroup) analysis in clinical trials
When the treatment effect on the outcome of interest is influenced by a baseline/demographic factor, investigators say that an interaction is present.
Effect Modifiers and Statistical Tests for Interaction in Randomized ...
In addition, the trial investigators may want to examine whether the observed treatment effect varies across patient subgroups (also called 'heterogeneity of ...
What a Clinician Ought to Know: Subgroup Analyses
WHAT ARE SUBGROUP ANALYSES? ... In randomized clinical trials, subgroup analyses evaluate the treatment effect (e.g., a hazard ratio [HR]) for a specific endpoint ...
Credibility of claims of subgroup effects in randomised controlled trials
In the 19 trials making more than one claim, only one (5%) checked the independence of the interaction. Of the 64 claims, 54 (84%) met four or ...
Statistics in Medicine — Reporting of Subgroup Analyses in Clinical ...
The research question usually posed is this: Do the treatment effects vary among the levels of a baseline factor? A subgroup analysis is sometimes undertaken to ...
Subgroup Analysis of Trials Is Rarely Easy (SATIRE): a study ...
Subgroup analyses in randomized trials examine whether effects of interventions differ between subgroups of study populations according to ...