Interleukin|17 governs hypoxic adaptation of injured epithelium

Interleukin-17 governs hypoxic adaptation of injured epithelium

IL-17A, which is produced by skin-resident γδ T cells, facilitates the adaptation of epithelium to hypoxia through HIF1α.

Interleukin-17 governs hypoxic adaptation of injured epithelium

Mammalian cells autonomously activate hypoxia-inducible transcription factors (HIFs) to ensure survival in low-oxygen environments.

Interleukin-17 governs hypoxic adaptation of injured epithelium - PMC

Epithelial repair requires cellular adaptation to the hypoxic wound microenvironment through evolutionarily conserved hypoxia-inducible factors (HIFs).

Interleukin-17 governs hypoxic adaptation of injured epithelium

Our findings underscore the coupling of inflammatory, metabolic, and migratory programs to expedite epithelial healing and illuminate the immune cell-derived ...

Interleukin-17 governs hypoxic adaptation of injured epithelium.

Abstract. Mammalian cells autonomously activate hypoxia-inducible transcription factors (HIFs) to ensure survival in low-oxygen environments. We report here ...

IL-17 signaling in skin repair: safeguarding metabolic adaptation of ...

describe that IL-17A produced by RORγt + γδ T cells governs wound epithelial ... Interleukin-17 governs hypoxic adaptation of injured epithelium.

Interleukin-17 governs hypoxic adaptation of injured epithelium

Request PDF | Interleukin-17 governs hypoxic adaptation of injured epithelium | Mammalian cells autonomously activate hypoxia-inducible transcription ...

Cutting edge: interleukin-17a prompts HIF1α for wound healing

Konieczny. Interleukin-17 governs hypoxic adaptation of injured epithelium. Science. (2022). G.L. Semenza. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer.

Metabolic coordination between skin epithelium and type 17 ...

Th17 cytokines interleukin (IL)-17 and IL ... 14. Konieczny, P. ∙ Xing, Y. ∙ Sidhu, I. ... Interleukin-17 governs hypoxic adaptation of injured epithelium.

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Skin deep: Epithelial cell metabolism and chronic skin inflammation

Konieczny et al. Interleukin-17 governs hypoxic adaptation of injured epithelium. Science. (2022). There are more references available in the ...

IL‐17: Balancing Protective Immunity and Pathogenesis - Sun - 2023

Additionally, IL-17 is also known to govern hypoxic adaptation of injured epithelium. [97]. Moreover, proper control of IL-17 might decrease ...

Cutting edge: interleukin-17a prompts HIF1α for wound healing

3. Konieczny, P. ... Interleukin-17 governs hypoxic adaptation of injured epithelium. Science. 2022; 377:eabg9302.

IL-17 in wound repair: bridging acute and chronic responses

Interleukin-17 governs hypoxic adaptation of injured epithelium. ... adaptation of wound epithelial cells. Signal Transduct Target Ther ...

Immune-Epithelial Cross Talk in Regeneration and Repair

65. Konieczny P, Xing Y, Sidhu I, Subudhi I, Mansfield KP et al. 2022. Interleukin-17 governs hypoxic adaptation of injured epithelium.

Can't Do It Alone: How the Skin Relies on the Immune System for ...

Thus, in the absence of IL-17a, epithelial cells could not activate HIF1a, which in turn prevented mice from properly healing skin injuries.

BIOGRAPHICAL SKETCH NAME: Shruti Naik eRA COMMONS ...

Cited >55 times. 2. Inflammatory memory in stem cells and tissue adaptation ... Interleukin-17 governs hypoxic adaptation of injured epithelium.

Targeting lymphoid-derived IL-17 signaling to delay skin aging

The proinflammatory cytokine interleukin 17 (IL-17) family members Il17a ... Interleukin-17 governs hypoxic adaptation of injured epithelium.

Shruti Naik, PhD - International Cytokine & Interferon Society

... cells, epithelial stem cells, and ... Oral Presentation at Cytokines 2021 Hybrid Meeting: INTERLEUKIN-17 GOVERNS HYPOXIC ADAPTATION OF INJURED EPITHELIUM.

IL-17A Orchestrates Reactive Oxygen Species/HIF1α–Mediated ...

, et al. 2022 . Interleukin-17 governs hypoxic adaptation of injured epithelium ... hypoxia by actively downregulating mitochondrial oxygen ...