Interstitial fluid pressure as an emerging biomarker in solid tumors

The physical microenvironment of cancer is characterized by elevated stiffness and tissue pressure, the main component of which is the ...

Elevated IFP is an established negative predictive and prognostic parameter, directly affecting malignant behavior and therapy response.

Tumor Interstitial Fluid Pressure as an Early-Response Marker for ...

Abstract. Solid tumors have a raised interstitial fluid pressure (IFP) due to high vessel permeability, low lymphatic drainage, poor perfusion, ...

Interstitial fluid pressure as an emerging biomarker in solid tumors

Interstitial fluid pressure as an emerging biomarker in solid tumors ; Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2022, № 5, p. 188792.

Interstitial fluid pressure in tumors: therapeutic barrier and biomarker ...

Interstitial fluid pressure is elevated in virtually all solid malignant tumors as a result of abnormalities of the vasculature and interstitium. High ...

Tumor Interstitial Fluid Formation, Characterization, and ... - Frontiers

Potential biomarkers will appear locally in high concentrations in tumors and may eventually be found diluted in the plasma. Access to TIF that reliably ...

Coevolution of Solid Stress and Interstitial Fluid Pressure in Tumors ...

The mechanical microenvironment of solid tumors is characterized by both fluid- and solid-phase stresses. Fluid-phase stresses include the vascular and ...

Interstitial fluid pressure in tumors: therapeutic barrier and biomarker ...

Interstitial pressure is elevated in solid tumors because of high VP, compressed, nonfunctional tumor lymphatic, high malignant CD and high IM (collagen) ...

Noninvasive Estimation of Tumor Interstitial Fluid Pressure ... - MDPI

The interstitial fluid pressure (IFP) is an important characteristic of the solid tumor microenvironment. Several studies reported a high IFP in ...

Interstitial Stress and Fluid Pressure Within a Growing Tumor

In addition, elevated interstitial fluid pressure (IFP) has been reported by researchers for seeral solid tumors (Sarntinoranont et al 2003) . The compromised ...

Reducing Interstitial Fluid Pressure and Inhibiting Pulmonary ...

Interstitial fluid pressure (IFP) in tumor is much higher than that in normal tissue, and it constitutes a great obstacle for the delivery ...

Absence of convection in solid tumors caused by raised interstitial ...

This study presents an analysis of the influence of interstitial fluid pressure on the chemotherapeutic effect in an HT29 human colon cancer xenograft mouse ...

Interstitial fluid pressure, vascularity and metastasis in ectopic ...

Solid tumours show interstitial fluid pressures (IFP) that are elevated above that of normal tissues. Tumour growth and development is supported ...

Morphology/Interstitial Fluid Pressure-Tunable Nanopomegranate ...

Morphology/Interstitial Fluid Pressure-Tunable Nanopomegranate Designed by Alteration of Membrane Fluidity under Tumor Enzyme and PEGylation.

Hydraulic conductivity of human cancer tissue: A hybrid study

Background Elevated tumor tissue interstitial fluid pressure (IFP) is an adverse biomechanical biomarker that predicts poor therapy response ...

Curvature-mediated rapid extravasation and penetration of ... - PNAS

Elevated interstitial fluid pressure (IFP) within pathological tissues (e.g., tumors, obstructed kidneys, and cirrhotic livers) creates a significant hindrance ...

Computational Modeling of Interstitial Fluid Pressure and Velocity in ...

The precipitous drop in IFP at the tumor periphery results in a zone where the interstitial fluid velocity (IFV) is increased and directed outward, causing ...

Mechanoimmunology in the solid tumor microenvironment

Tissue elasticity properties as biomarkers for prostate cancer ... R.K.. (. 2013. ) Coevolution of solid stress and interstitial fluid pressure in tumors during ...

High Interstitial Fluid Pressure Is Associated with Tumor-Line ... - PLOS

High IFP has been associated with low radiocurability and high metastatic frequency in human melanoma xenografts and with poor survival after radiation therapy ...

Characterization of Microvascular Invasion in Hepatocellular ...

Background Most solid tumors show increased interstitial fluid pressure (IFP), and this increased IFP is an obstacle to treatment.