Intraplantar injection of tetrahydrobiopterin induces nociception in ...

Tetrahydrobiopterin (BH4) is implicated in the development and maintenance of chronic pain. After injury/inflammation, the biosynthesis of ...

Intrathecal injections of BH4 have been shown to induce and enhance pain-like behaviours in rats, suggesting that under chronic pain conditions BH4 may act by ...

Intraplantar injection of tetrahydrobiopterin induces nociception in ...

Tetrahydrobiopterin induces pro-nociceptive effects following peripheral injection. Local pre-treatment with morphine attenuate tetrahydrobiopterin evoked ...

Intraplantar injection of tetrahydrobiopterin induces nociception in ...

Intraplantar injection of tetrahydrobiopterin induces nociception in mice. by Arafat Nasser, Sawsan Ali, Signe Wilsbech, Ole J Bjerrum, Lisbeth B Møller.

Intraplantar injection of tetrahydrobiopterin induces nociception in ...

Dive into the research topics of 'Intraplantar injection of tetrahydrobiopterin induces nociception in mice'. Together they form a unique fingerprint. Sort by ...

Impaired behavioural pain responses in hph-1 mice with ... - NCBI

Intraplantar injection of CFA into the hind-paw of WT mice induced a long-term mechanical hypersensitivity, starting on day 1 and persisting ...

Reduction of Neuropathic and Inflammatory Pain through Inhibition ...

Constitutive BH4 overproduction in sensory neurons increases pain sensitivity, whereas blocking BH4 production only in these cells reduces nerve injury-induced ...

Nitric Oxide in the Spinal Cord Is Involved in the Hyperalgesia ...

Chronic Restraint Stress-Induced Analgesia Was Attenuated by DAHP and Exacerbated by Intrathecal Injection of Tetrahydrobiopterin Into the ...

GCH1 variants, tetrahydrobiopterin and their effects on pain ...

Intraplantar injection of tetrahydrobiopterin induces nociception in mice · A. NasserS. AliSigne WilsbechO. BjerrumL. Møller. Biology, Medicine. Neuroscience ...

Kynurenine and Tetrahydrobiopterin Pathways Crosstalk in Pain ...

This review will focus on the KYN/BH4 crosstalk in chronic pain and the potential modulation of these metabolic pathways that could induce analgesia without ...

GCH1 variants, tetrahydrobiopterin and their effects on pain sensitivity

Fig. 4A shows the effect of 180–350 mg/kg DAHP on mechanical pain hypersensitivity 24 h after CFA-induced paw inflammation. Statistical analysis ...

Mast cell–derived BH4 and serotonin are critical mediators of ...

Mice deficient in mast cells or in mast cell–specific Gch1 or Tph1 showed drastically decreased postoperative pain. We found that injury induced ...

Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway ...

Møller, Intraplantar injection of tetrahydrobiopterin induces nociception in mice. Neurosci. Lett. 584, 247–252 (2015). 24. A. Latremoliere ...

Mast cell-derived BH4 is a critical mediator of postoperative pain

A single intradermal injection of substance P induced pain ... Intraplantar injection of tetrahydrobiopterin induces nociception in mice.

GCH1 variants, tetrahydrobiopterin and their effects on pain sensitivity

Briefly, as this is not the focus of this thesis, GCH1 polymorphisms associated with a lower GTPCH activity are often linked to lower pain perception and an ...

GCH1 variants, tetrahydrobiopterin and their effects on pain sensitivity

Effect of 270 mg/kg DAHP on formalin-induced pain. (A) 20 ␮l of 2.5% (v/v) formalin was injected intraplantar into one hind-paw and the time spent licking or ...

21750 - Sigma-Aldrich

Intraplantar injection of tetrahydrobiopterin induces nociception in mice. ... Fufang Kushen injection inhibits sarcoma growth and tumor-induced ...

TRPV1 and TRPA1 Mediate Peripheral Nitric Oxide-Induced ... - PLOS

We show that BH4-induced calcium influx is ablated in DRG neurons from TRPA1/TRPV1 double knockout mice, suggesting that production of endogenous levels of NO ...

Nitric Oxide in the Spinal Cord Is Involved in the Hyperalgesia ...

... induced persistent pain., Pain, № 119, с. 113 https://doi ... Nasser, Intraplantar injection of tetrahydrobiopterin induces nociception in mice., Neurosci.

Kynurenine and Tetrahydrobiopterin Pathways Crosstalk in Pain ...

a single or repeated SPR inhibitor intraperitoneal injection alleviated intraplantar CFA injection-, SNI-, and CCI-induced pain ...