Intratumoral injection of radioactive Astatine

Intratumoral injection of radioactive Astatine (211At) microspheres ...

Background: Our aims were to prepare microspheres labelled with radioactive astatine as brachytherapy seeds and to confirm the antitumor ability of these ...

Intratumoral administration of astatine-211-labeled gold ...

Assuming that the radionuclides are not scattered externally from the tumor, extremely high doses of radioactivity could be administered ...

Intratumoral administration of astatine-211-labeled gold ... - NCBI

At is a high-energy α-ray emitter with a relatively short half-life and a high cytotoxicity for cancer cells. Its dispersion can be imaged using ...

Brain intratumoural astatine-211 radiotherapy targeting syndecan-1 ...

Brain intratumoural astatine-211 radiotherapy targeting syndecan-1 leads to durable glioblastoma remission and immune memory in female mice.

Intratumoral injection of radioactive Astatine (211At) microspheres ...

Intratumoral injection of radioactive Astatine (211At) microspheres for the treatment of tumors. INTRODUCTION. Together with surgery and chemotherapy ...

Brain intratumoural astatine-211 radiotherapy targeting syndecan-1 ...

After MRI validation of tumour presence at day 11, TAT was injected at the same coordinates. Biodistribution, efficacy, toxicity, local and ...

Brain intratumoural astatine-211 radiotherapy targeting syndecan-1 ...

tion of radioactivity 2 h post-injection ... Intratumoral administration · of astatine-211-labeled gold nanoparticle for alpha therapy.

(PDF) Intratumoral administration of astatine-211-labeled gold ...

3E). ... injected with 120 nm or 30 nm 211At-AuNP-S-mPEG. ... uted almost throughout the entire tumor (Fig. 4B). ... All the animals survived for 38 ...

Astatine-211-Labeled Gold Nanoparticles for Targeted Alpha ... - MDPI

Alpha-particle radiotherapy has gained considerable attention owing to its potent anti-cancer effect. 211At, with a relatively short half-life of 7.2 h, ...

[PDF] Intratumoral administration of astatine-211-labeled gold ...

Astatine-211-Labeled Gold Nanoparticles for Targeted Alpha-Particle Therapy via Intravenous Injection · Medicine. Pharmaceutics · 2022.

Astatine-211 based radionuclide therapy: Current clinical trial ...

Astatine-211 (211At) has physical properties that make it one of the top candidates for use as a radiation source for alpha particle-based ...

New Understanding of Astatine's Chemical Properties Will Aid ...

One isotope, astatine-211 (At-211, which has a 7.2-hour half-life), is among the most promising alpha emitters for cancer therapy. In this ...

Astatine-211: Japan's strategic weapon against cancer - Nature

Researchers in Japan are developing world-leading expertise in making and using the alpha particle emitter, astatine-211 ( 211 At), which has potential for use ...

Targeted cancer therapies: Getting radioactive atoms to accumulate ...

Compounds containing astatine-211 (211At) can be used in targeted radiotherapies for prostate cancer, but deastatination in the body remains ...

New Understanding of Astatine's Chemical Properties Will Aid ...

This research enhances astatine radiolabeling procedures and advances the development of TAT drugs. Understanding astatine's chemical behavior ...

Tissue distribution and radiation dosimetry of astatine-211-labeled ...

Over the 48-h observation period, the distribution of 211At- and 131I-labeled antibody were quite similar in tumor and normal tissues except stomach. These data ...

211At-labeled immunoconjugate via a one-pot three-component ...

Intratumoral injection of 5 mL of each 0.05% PBS-T solution ... The toxicity by astatine radioactivity under the experimental.

Astatine-211 radiolabelling chemistry: from basics to advanced ...

211At-radiopharmaceuticals are currently the subject of growing studies for targeted alpha therapy of cancers, which leads to the widening ...

Astatine-211 Radiotheranostics: A New Era in Cancer Treatment

Its ability to deliver high-energy radiation directly to cancer cells while sparing healthy tissues makes it an ideal therapeutic agent. Astatine-211 possesses ...

(PDF) Astatine-211-Labeled Gold Nanoparticles for Targeted Alpha ...

The in vivo biodistribution results showed the accumulation of 5 nm 211At-AuNPs@mPEG at 2.25% injection dose per gram (% ID/g) in tumors within ...