Investigating allosteric regulation by membrane domains of two ...

Investigating allosteric regulation by membrane domains of two pentameric ligand-gated ion channels ... membrane domain markers. Article ...

1095-Pos. Investigating allosteric regulation by membrane domains of two pentame- ric ligand-gated ion channels. Nate Rogers1, Isabel Varghese2, ...

Investigating allosteric regulation by membrane domains of two ...

NASA/ADS · Investigating allosteric regulation by membrane domains of two pentameric ligand-gated ion channels.

Investigating the allosteric response of the PICK1 PDZ domain to ...

Here, we use all‐atom molecular dynamics simulations to explore dynamic allostery in the PICK1 PDZ domain by modeling two PICK1 PDZ systems: PICK1 PDZ‐DAT and ...

Allosteric regulation of Arf GTPases and their GEFs at the membrane ...

An essential step is their activation by guanine nucleotide exchange factors (GEFs), whose Sec7 domain stimulates GDP/GTP exchange. ArfGEFs form 2 major ...

[1607.06836] Allosteric Regulation by a Critical Membrane - arXiv

Many of the processes that underly neural computation are carried out by ion channels embedded in the plasma membrane, a two-dimensional liquid ...

Investigating the allosteric response of the PICK1 PDZ domain to ...

Here, we use all-atom molecular dynamics simulations to explore dynamic allostery in the PICK1 PDZ domain by modeling two PICK1 PDZ systems: ...

NMR Investigations of Allosteric Processes in a Two-domain ...

In vivo this interdomain allosteric regulation is enhanced by multiple co-chaperone proteins that modulate substrate binding as well as nucleotide hydrolysis ...

Investigating the Allosteric Regulation of YfiN from Pseudomonas ...

YfiN, also called TpbB, is a multi-domain membrane enzyme connecting periplasmic stimuli to cytosolic c-di-GMP production by an allosteric inside-out signaling ...

Dynamic inter-domain transformations mediate the allosteric ...

Eukaryotic MTHFR appends to the well-conserved catalytic domain (CD) a unique regulatory domain (RD) that confers feedback inhibition by SAM.

Allosteric regulation by membranes and hydrophobic subsites in ...

In Figure 5, the catalytic domain of human GIVA cPLA2 was placed in a cube of water and a substrate sn-1 palmitoyl, sn-2 arachidonyl phosphatidylcholine (PAPC) ...

Mechanism of allosteric regulation of β2-adrenergic receptor ... - eLife

... membranes and supports the dynamic assembly of nanoscale membrane domains (Simons and Ikonen, 2000). The best known case is β2AR, which is a ...

Molecular basis for allosteric regulation of the type 2 ryanodine ...

To investigate the mechanism for the requirement of synergistic action of ATP/caffeine/Ca2+ to open RyR2 in the presence of FKBP12.6, the central domains and ...

Allosteric regulation of exocyst: Discrete activation of tethering by ...

Instead, it contains a PH domain, followed by two CATCHR domains. ... two different locations—on the plasma membrane and in the cytoplasm.

Allosteric Regulation at the Crossroads of New Technologies

Examining proteins as dynamic regulatory machineries that fluctuate ... Allosteric signalling in the outer membrane translocation domain of PapC usher.

A parametrized two-domain thermodynamic model explains ... - eLife

The nuanced mutational effect on allosteric regulation is linked apparently to the equilibria among different conformational and binding states ...

Role of the loop L4,5 in allosteric regulation in mtHsp70s

Further, to investigate the in vivo functional significance of a loop L4,5 in domain communication and protein import, we generated the ...

Change in Allosteric Network Affects Binding Affinities of PDZ Domains

Therefore, it is critical to have knowledge of how the allosteric transition occurs in PDZs. We investigate the allosteric response of the two most studied ...

Mapping the allosteric network within a SH3 domain - Nature

... two residues under investigation A and B. The ... Allosteric control of regulated scaffolding in membrane-associated guanylate kinases.

Allosteric regulation in STAT3 interdomains is mediated by a rigid core

STAT3 functions as a dimer mediated by phosphorylation of the SRC-homology 2 (SH2) domain, a key target for therapeutic drugs. While great efforts have been ...