Investigating the Effects of Brain Cholesterol Metabolism Using ...

CYP46A1 restoration in striatal neurons using the adeno-associated virus (AAV) therapy AB-1001 led to reduced mutant Huntingtin protein aggregation and improved ...

Abstract Details - American Academy of Neurology

Abstract Details. Title Investigating the Effects of Brain Cholesterol Metabolism Using CYP46A1 Gene Therapy in Subjects with Huntington's Disease. Topic ...

Brain Cholesterol Metabolism, Oxysterols, and Dementia - PMC - NCBI

Myelin disruption is likely to be an important source of excess cholesterol in the brain during the aging and neurodegenerative disease processes. Myelin ...

CYP46A1 gene therapy deciphers the role of brain cholesterol ...

Dysfunctions in brain cholesterol homeostasis have been extensively related to brain disorders. The main pathway for brain cholesterol ...

Investigating the Effects of Brain Cholesterol Metabolism Using ...

Results: We found that CYP46A1 reduces the quantity and size of mutant huntingtin aggregates in cells, as well as the levels of mutant ...

Researchers develop new method to map cholesterol metabolism in ...

It is known that cholesterol is not evenly distributed across different brain regions; however, up until now there has been no technology ...

Lowering a form of brain cholesterol reduces Alzheimer's-like ...

Louis have found that a form of cholesterol known as cholesteryl esters builds up in the brains of mice with Alzheimer's-like disease, and that ...

Brain cell type-specific cholesterol metabolism and implications for ...

Cholesterol metabolism in both neurons and glial cells contributes to learning and memory. Astrocytes not only provide metabolic substances to neurons, but can ...

Neurodegeneration: The role of cholesterol metabolism

A recent study investigated the link between neurodegenerative disease proteins and defective cholesterol metabolism. · The results indicate that ...

Impaired Cholesterol Metabolism, Neurons, and Neuropsychiatric ...

Cholesterol metabolism plays an essential role in cellular functions (including as a component of the plasma membrane, as an energy source, ...

Abnormal brain cholesterol homeostasis in Alzheimer's disease—a ...

Our results suggest that reduced de novo cholesterol biosynthesis may occur in response to impaired enzymatic cholesterol catabolism and efflux to maintain ...

Brain Cholesterol: Long Secret Life Behind a Barrier - AHA Journals

Under steady-state conditions, most of the de novo synthesis of cholesterol in the brain appears to be balanced by excretion of the cytochrome P ...

Brain cholesterol metabolism and neurologic disease

Abnormalities in cholesterol metabolism in the CNS occur in several neurologic disorders, including Niemann-Pick type C 5 and Smith-Lemli-Opitz syndrome.

Balancing cholesterol in the brain: from synthesis to disposal

Consequently, cholesterol synthesis and turnover must be tightly regulated to ensure steady levels of sterol in the brain. Cholesterol biosynthesis is a ...

Cholesterol in brain disease: sometimes determinant and frequently ...

Age‐associated cholesterol reduction was also observed in postmortem human samples 30. Importantly, the rate of cholesterol synthesis in individual brain cells ...

Cholesterol Metabolism in the Brain and Its Association with ...

In addition, cholesterol lowering drugs, statins have been reported to exert beneficial effects in many neurodegenerative diseases [10]. However ...

Diabetes and Insulin in Regulation of Brain Cholesterol Metabolism

These changes are due, at least in part, to direct effects of insulin to regulate these genes in neurons and glial cells and can be corrected by ...

Abnormal brain cholesterol homeostasis in Alzheimer's disease—a ...

Finally, using regional brain transcriptomic data, we performed genome-scale metabolic network modeling to assess alterations in cholesterol ...

Cholesterol metabolism: physiological versus pathological...

Cholesterol is an essential structural component of plasma membranes (PMs) in the brain and peripheral tissue (Luo et al., 2020) and forms and maintains cell ...

Brain cholesterol metabolism and Parkinson's disease — Penn State

Conclusions: Results indicate that plasma (S)24-OH-cholesterol (possibly reflecting brain cholesterol metabolism) is inversely linked to PD, is relatively ...