- Contribution of Ion Channels in Pain Sensation🔍
- Ion Channels Involved in Pain🔍
- Ion Channels Relevant to Pain🔍
- Recent advances in targeting ion channels to treat chronic pain🔍
- An overview of ion channels therapeutics in the treatment of pain🔍
- Ion Channel Genes in Painful Neuropathies🔍
- Review Plant|derived natural products targeting ion channels for pain🔍
- Ion channels involved in inflammation and pain in osteoarthritis and ...🔍
Ion Channels Relevant to Pain
Editorial: Role of Ion Channels in Pain - PMC
Among these channels, sodium, calcium, transient receptor potential (TRP), and PIEZO and purinergic P2X3 channels have been reported in the basic biology of ...
Contribution of Ion Channels in Pain Sensation | Alomone Labs
Another important and well-documented player in pain processing is the P2X3 ion channel. The P2X3 channel belongs to the ligand gated ion channel family that ...
Ion Channels Involved in Pain - News-Medical
Although all six families play wide and varying roles in several physiological and pathophysiological processes, the TRPV1, TRPM8, and TRPA1 ...
This chap- ter is limited to a discussion of voltage-dependent calcium and sodium channels, as well as certain members of the families of potassium and acid- ...
Recent advances in targeting ion channels to treat chronic pain - PMC
Sensitization can also lead to allodynia (where non‐noxious stimuli are perceived as noxious pain). Of relevance here is that a range of animal models of pain ...
An overview of ion channels therapeutics in the treatment of pain
Of the ion channels, Na+ and Ca2+, which play a vital role in pain, lead the ion channel pipeline. Therefore, we have reviewed the current research trends and ...
Ion Channel Genes in Painful Neuropathies - MDPI
Currents of Kv channels have been detected in peripheral neurons (including DRG) and linked to pain pathways [45]. A decreased density of Kv channels has been ...
Review Plant-derived natural products targeting ion channels for pain
are important determinants of sensory neuron excitability: they are essential for the initial transduction of sensory stimuli, the electrogenesis of the action ...
Ion channels involved in inflammation and pain in osteoarthritis and ...
In sensory nerve cells, both TRPV1 and ASIC3 have been implicated in mediating OA-related pain (41, 42). The TRPV1 antagonist APHC3 ...
Decoding Ion Channels: Bridging Physiological Pain and the ...
Ion channels are central to both the physiological pain response and the pathophysiological changes that underlie chronic pain.
Role of Ion Channels in Pain | Frontiers Research Topic
Ion channels allow ions to pass through cell membrane and are essential for a host of cell functions in many organs. Due to localization in primary sensory ...
Ion channels in nociceptors - Neurology.org
Nociceptors express a unique repertoire of voltage-gated sodium (Na + ) channels (Na v ), potassium (K + ) and calcium (Ca 2+ ) channels, as well as cation ...
Gene Therapy Treats Chronic Pain by Dialing Down Sodium - NYU
One particular sodium ion channel called NaV1.7 emerged as a promising target for treating pain following the discovery of its importance in ...
Full article: Ion channel therapeutics for pain
More recently, evidence for the role of ion channels in pain has come from the study of monogenic pain related diseases caused by mutations that affect the ...
Calcium-Permeable Ion Channels in Pain Signaling
Long-term changes in ion channel expression and function are thought to contribute to chronic pain states. Many of the channels involved in the ...
Exploring chronic pain: TRP ion channels as promising targets for ...
TRP ion channels are central to the pain-signaling apparatus in our nervous system. The potential for developing a therapeutic intervention that ...
Among these channels, sodium (eg. NaV1.7 and NaV1.8), calcium, transient receptor potential (TRP), and PIEZO and purinergic P2X3 channels have been ...
Modulatory Action of Voltage-gated Ion Channels in Inflammation ...
The origin of every pain syndrome is inflammation. A group of voltage-gated channels that are permeable to calcium ions enhances sensory transduction witnessed ...
Ion channels in cancer-induced bone pain - Frontiers
Therefore, in this review, we summarize the current literature on ion channels, related receptors, and drugs and explore the mechanism of CIBP. Targeting ion ...
Ion channels involved in spontaneous pain - Science Repository
It is believed that voltage-gated Na+ channels (VGSCs) and Ca2+ channels (VGCCs) are the primary membrane proteins for causing spontaneous pain.