Is bone density a valid surrogate for fracture?

is bone density a valid surrogate for fracture? - PubMed

In the treatment of osteoporosis using anti-resorptive agents there has been increasing interest in quantifying the relationship between fracture endpoints ...

Statistical validation of surrogate endpoints: Is bone density a valid surrogate for fracture? Z. Li1, A.A. Chines2, M.P. Meredith1. 1 Department of ...

Validation of the Surrogate Threshold Effect for Change in Bone ...

In the field of osteoporosis, we have proposed that change in bone mineral density (BMD) of the total hip could be a surrogate outcome for fracture risk ...

Bone mineral density as a surrogate biomarker for fracture risk ...

which showed a causal association between improvements in bone mineral density (BMD) and reduction in fracture risk. We welcome these findings for their ...

The validation of bone mineral density (BMD) as a surrogate outcome for fracture would allow the size of future randomised controlled osteoporosis ...

The validation of bone mineral density (BMD) as a surrogate outcome for fracture would allow the size of future randomised controlled ...

is bone density a valid surrogate for fracture? - Semantic Scholar

A review of definitions of surrogate endpoints and requirements for their statistical validation indicates that the actual BMD value is correlated with ...

Surrogates for Fracture Endpoints in Clinical Trials

For formation stimu- lating agents, BMD may well be a valid surrogate ... 2002 Relationships between bone mineral density and incident vertebral fracture risk ...

analysis from the FNIH-ASBMR SABRE project | Journal of Bone ...

A BMD value (T-score) 2.5 SDs or more below the mean for young adults is commonly used to define higher fracture risk and is incorporated into ...

Endpoints beyond fracture promise to facilitate shorter trials, new ...

Investigators have now proposed a validated alternative outcome for fracture — change in bone mineral density — to serve as a surrogate endpoint ...

FDA Issues Timeline for Determination on FNIH-ASBMR-SABRE ...

“Embracing BMD as a surrogate endpoint in clinical trials will revolutionize the journey of novel therapeutic agents to the clinic, reducing ...

Bone Strength and Surrogate Markers: The First, Second, and Third ...

lumbar spine bone mineral density and vertebral fracture risk reduc- tion in teraparatide-treated postmenopausal women with osteopo- rosis. J Bone Miner Res.

Hip BMD changes explained substantial proportions (44–67%) of treatment-related fracture risk reduction. Interpretation Treatment-related BMD changes are ...

Percent change in bone mineral density (BMD) as a surrogate ...

Percent change in bone mineral density (BMD) as a surrogate endpoint for fractures · the post value must be linearly related to the pre value ...

Surrogate endpoints for fractures

Surrogate Endpoints in Clinical Trials for osteoporosis: ✓ are they ... Reduction in fracture risk in relation to BMD. ✓ Bisphosphonates. ✓ HRT.

Greater Increases in Bone Mineral Density Do Not Relate to Greater ...

Low bone mineral density (BMD) is correlated with increased fracture risk. Whether greater BMD increases induced by osteoporosis drugs are related to ...

Bone Density Testing to Monitor Osteoporosis Therapy in Clinical ...

BMD is a surrogate marker for bone strength and fracture risk; stability or a significant increase in BMD is an acceptable response to ...

Bone turnover assessment: a good surrogate marker? - SciELO

To asses fracture risk, bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is the most commonly used tool. The search for ...

Diminishing Value from Multiple Serial Bone Densitometry in ...

Statistical validation of surro- gate endpoints: is bone density a valid surrogate for fracture? J. Musculoskelet Neuronal Interact. 2004;4(1): ...

Validation of the Surrogate Threshold Effect for Change in BMD as a ...

We found that the STEs for all, vertebral, hip, and non‐vertebral fractures were 1.83, 1.42, 3.18, and 2.13%, respectively. Among trials used to ...