Ketamine's antidepressive effects tied to opioid system in brain

Ketamine's antidepressive effects require activation of opioid receptors in the brain, a new Stanford study shows.

Opioid Receptor Antagonism Attenuates Antidepressant Effects of ...

In addition to N-methyl D-aspartate receptor antagonism, ketamine produces opioid system activation. The objective of the study was to ...

Researchers find response to ketamine depends on opioid ...

In 2018, a small clinical trial by Stanford Medicine researchers found that ketamine's antidepressant effects could be suppressed by first ...

The endogenous opioid system in the medial prefrontal cortex ...

As mPFC plays an important role in regulating ketamine's antidepressant-like effects [12, 13], we sought to determine whether localized blockade ...

Ketamine's Antidepressant Effects: Opioid Role - Bespoke Treatment

Ketamine's antidepressive effects tied to opioid system in brain ... Ketamine's antidepressive effects require activation of opioid receptors in ...

Unraveling the opioid actions of S-ketamine and R-ketamine - Nature

Answering these questions is important and may have public health consequences. Ketamine has a well-documented rapid antidepressant effect when ...

Ketamine – More mechanisms of action than just NMDA blockade

Its hypnotic effects appear to be largely mediated by blockade of NMDA and HCN1 receptors, but cholinergic, aminergic, and opioid systems appear to play both a ...

Inside Stanford Medicine - Sept. 10, 2018

Ketamine's antidepressive effects require activation of opioid receptors in the brain, a new Stanford study shows. The surprising finding may ...

Opioid system is necessary but not sufficient for antidepressive ...

Thus, ketamine does not act as an opiate but its effects require both NMDA and opiate receptor signaling, suggesting that interactions between ...

Ketamine's antidepressant effect may require opioid system activation

Findings from a double-blind crossover study indicated that ketamine's acute antidepressant effect involves the activation of the brain's ...

Ketamine, A Promising Depression Treatment, Seems To Act ... - NPR

A Stanford research team finds that ketamine's ability to quickly relieve depression may depend on activating the brain's opioid system.

Antidepressant ketamine might affect the brain like an opioid - Science

Ketamine, a drug that's shown promising results in a number of small studies as a treatment for depression, could be producing its effects by lighting up the ...

Hydroxynorketamine Interacts with μ and κ Opioid Receptors

Given clinical evidence that pretreatment with naltrexone attenuates the antidepressant effect of ketamine, (1) we hypothesized that naltrexone ...

Ketamine's Antidepressant Benefits Tied to the Brain's Opioid System

A new study of ketamine's effects on the brain illuminates the connections between depression, pain, and opioid addiction. Researchers at ...

The opioid system in depression - ScienceDirect.com

While buprenorphine has been shown to increase place preference in mice, this effect was blocked with naltrexone suggesting this is related to buprenorphine's ...

Mechanisms of Ketamine and its Metabolites as Antidepressants

Based on studies that detail the onset of drug-induced effects in humans, ketamine (0.5 mg/kg i.v. over 40 minutes) produces illusory experiences, increases in ...

Brain's opioid system plays a key role in ketamine's antidepressant ...

A study found ketamine's rapid antidepressant effects in rats hinge on activating the brain's opioid system, particularly β-endorphin in the ...

Bridging rapid and sustained antidepressant effects of ketamine

Ketamine's antidepressant effects are triggered by N-methyl-d-aspartate (NMDA) receptor blockade that impacts intracellular signaling to produce ...

Ketamine and hydroxynorketamine as novel pharmacotherapies for ...

Evidence supports the notion that ketamine, an anesthetic and rapid-acting antidepressant drug, holds promise as a candidate for OUD treatment, including the ...

What ketamine can teach us about the opioid system in depression?

Although the efficacy of ketamine for treating. MDD has been reported after single intravenous infusion, keta- mine's antidepressant effects ...