Key mechanism for kidney disease identified

Penn Researchers Identify Key Mechanism of Kidney Disease

Penn researchers identify changes in NAD metabolism in both mouse and human kidneys; findings could lead to new drugs to prevent and treat ...

Scientists identify key pathway underlying kidney disease

The renal tubules are involved in the reabsorption of nutrients and other useful small molecules back into the bloodstream while eliminating ...

Molecular Mechanisms of Kidney Injury and Repair - PMC

Key contributors to kidney injury and to the AKI-to-CKD transition include macrophages, the different forms of regulated cell death and necroinflammation, ...

Mechanisms of progression of chronic kidney disease - PMC

We will review possible mechanisms of progressive renal damage, including systemic and glomerular hypertension, various cytokines and growth factors.

Penn researchers identify key mechanism of kidney disease

The study was conducted by co-lead investigators Katalin Susztak, professor of nephrology and co-chair of the Kidney Innovation Center at Penn ...

Signaling pathways of chronic kidney diseases, implications for ...

In this review, we discussed the key signaling pathways mediated by lipotoxicity, OS, inflammation, and myofibroblasts activation of CKD. And ...

Kidney Disease Surveillance System

When people develop chronic kidney disease (CKD), their kidneys become damaged and over time may not clean the blood as well as healthy kidneys. If kidneys do ...

Advances in kidney disease research | AstraZeneca

There is an unmet need in CKD. In addition to the increasing prevalence and limited treatment options, CKD is known as a 'disease multiplier'. As such, CKD is ...

Chronic kidney disease (CKD) - Symptoms, causes, treatment

Chronic kidney disease (CKD), also known as chronic kidney failure, means a gradual loss of kidney function over time. Chronic means the damage happens ...

Penn Researchers Unlock Genetic 'Treasure Map' for Chronic ...

Though diabetes and high blood pressure play key roles in chronic kidney disease development, the disease has a strong heritable component, and ...

Cellular and Molecular Mechanisms of Chronic Kidney ... - Frontiers

Since a better understanding of the common cellular and molecular mechanisms of these diseases may be a key to successful identification of new therapeutic ...

Molecular pathways that drive diabetic kidney disease - JCI

The TRPC channels TRPC5, TRPC6, and ORAI have been identified as key balancers of intracellular calcium levels in podocytes (95, 96). Cytosolic ...

New Insights into Molecular Mechanisms of Chronic Kidney Disease

Elevated levels of oxidative stress have already been found in the early stages of CKD, which is correlated with the progression to end-stage renal disease. The ...

Novel Biomarkers of Kidney Function Introduction and Overview

After sepsis or ischemic injury, renal tubular cells enter a brief period of cell cycle arrest, a key mechanism implicated in AKI. In the ...

The systemic nature of CKD | Nature Reviews Nephrology

Chronic kidney disease (CKD) affects numerous organs and systems, which in turn have effects on kidney function.

7 Things to Know About Kidney Function | National Kidney Foundation

There are many causes of chronic kidney disease. The kidneys may be affected by diseases such as diabetes and high blood pressure. Some kidney conditions are ...

Chronic Kidney Disease - Province of British Columbia - Gov.bc.ca

CKD is defined as an abnormality of kidney structure or function that is present for greater than 3 months. The two key parameters for ...

New compound stops progressive kidney disease in its tracks

But the team didn't stop there. The researchers predicted that the TRPC5 mechanism might play a similar role in other types of progressive ...

Molecular mechanisms of diabetic kidney disease - JCI

Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide and the single strongest predictor of mortality in patients with diabetes.

Preventing the gut dysbiosis and maintaining the gut microbiota homeostasis are considered the key mechanisms for hampering the setting of ...