Kras in metastatic colorectal cancer

Role of oncogenic KRAS in the prognosis, diagnosis and treatment ...

Colorectal cancer (CRC) is a heterogeneous disease at the cellular and molecular levels. Kirsten rat sarcoma (KRAS) is a commonly mutated ...

The Therapeutic Landscape for KRAS-Mutated Colorectal Cancers

Mutations of the KRAS gene occur in ~40% of metastatic colorectal cancers. While this cohort has historically been difficult to manage, the last ...

The current understanding on the impact of KRAS on colorectal cancer

In CRC, KRAS mutations lead to abnormal activation of the RAS/RAF/MEK/ERK signaling pathway. It is reported that KRAS mutations upregulates IGF-1R expression ...

Colorectal Cancer and KRAS/BRAF - Medscape Reference

Approximately 30-50% of colorectal tumors are known to have a mutated (abnormal) KRAS, indicating that up to 50% of patients with CRC might ...

Prognostic significance of KRAS gene mutations in colorectal cancer

KRAS mutations in colon cancers have been associated with a poorer survival and increased tumor aggressiveness. Additionally, KRAS mutations in colorectal ...

Understanding the KRAS Mutation in Colorectal Cancer - Healthline

And research shows it's linked to treatment resistance and worsened survival rates. If you receive a colorectal cancer diagnosis, KRAS mutation ...

FDA Approves First Colorectal Cancer Treatment that Targets KRAS ...

Mutations in the KRAS gene — one of the first cancer genes ever identified — are most commonly found in colorectal cancer, pancreatic cancer, ...

Targeting KRAS G12C Is a Significant Milestone in Metastatic ...

Colorectal cancer (CRC) is the second most common cancer worldwide, and KRAS mutations exist in 40% of metastatic CRC cases; therefore, ...

KRAS - Fight Colorectal Cancer

KRAS mutations are found in about 40% of colorectal cancers. This means approximately 60% of colorectal cancers have wild-type (WT) KRAS. KRAS mutations ...

Setting Off on the Mission to Target KRAS in Colorectal Cancer

Approximately 20% of all cancers harbor an activating RAS mutation, 75% of which are Kirsten rat sarcoma (KRAS) mutations.

KRAS allelic imbalance drives tumour initiation yet suppresses ...

We and others have previously shown that oncogenic Kras cooperates with Apc loss in driving colorectal tumorigenesis. The majority of studies to ...

Frequency of Specific KRAS Mutations, and Their Impact on ...

Specific gene mutations, including KRAS, are linked to poor prognosis in metastatic colorectal cancer (mCRC) patients. We found that survival ...

Adagrasib with or without Cetuximab in Colorectal Cancer with ...

KRAS G12C mutations occur in approximately 3 to 4% of patients with metastatic colorectal cancer and are associated with shorter survival than ...

KRAS Biomarker | Colorectal Cancer Alliance

Approximately 40-45 percent of colorectal cancer patients have a KRAS mutation in their tumor. A KRAS mutation is not hereditary (a germline mutation) and will ...

KRAS inhibition in metastatic colorectal cancer: An update

In this review, we discuss clinical efforts to target KRAS in colorectal cancer from studies of downstream inhibitors to recent direct inhibitors of KRAS G12C ...

Codon-specific KRAS mutations predict survival benefit of trifluridine ...

Using whole-genome analysis of 37 patients with metastatic colorectal cancer (mCRC) treated with the chemotherapy trifluridine/tipiracil (FTD/ ...

Prognostic value of specific KRAS mutations in patients with ...

There is little evidence on KRAS mutational profiles in colorectal cancer (CRC) peritoneal metastases (PM). This study aims to determine the ...

Metformin selectively inhibits metastatic colorectal cancer with the ...

Aberrant KRAS signaling plays a crucial role in cancer cell proliferation and is commonly associated with poor prognosis and resistance to anti- ...

KRAS mutation in colon cancer: What does it mean?

A mutation in the KRAS gene can lead to uncontrollable cell growth and the development of cancer. Having this mutation can significantly influence the ...

Targeting KRAS G12C Mutation in Colorectal Cancer, A Review

KRAS G12C mutations are present in a small percentage of metastatic colorectal cancer patients [9]. However, it is associated with a poor response to standard ...