LRPPRC is necessary for polyadenylation and coordination of ...

Regulation of mtDNA expression is critical for maintaining cellular energy homeostasis and may, in principle, occur at many different levels ...

LRPPRC forms an RNA‐dependent protein complex that is necessary for maintaining a pool of non‐translated mRNAs in mammalian mitochondria. Loss of LRPPRC does ...

LRPPRC is necessary for polyadenylation and coordination ... - Scite

Trusted by researchers and organizations around the world · Mitochondrial O-GlcNAc Transferase (mOGT) Regulates Mitochondrial Structure, Function, and Survival ...

The Leucine-rich Pentatricopeptide Repeat-containing Protein ...

Significance: LRPPRC is an essential post-transcriptional regulator of metazoan mtDNA expression. Previous article ...

LRPPRC is necessary for polyadenylation and ... - Synapse

LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs. Abstract: Regulation of mtDNA expression is critical for ...

Drosophila melanogaster LRPPRC2 is involved in ... - PubMed

We have previously shown that the mammalian LRPPRC protein and its Drosophila melanogaster homolog DmLRPPRC1 (also known as bicoid stability ...

[PDF] LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay ...

LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria · 162 Citations · 54 References.

Structural basis of LRPPRC–SLIRP-dependent translation by the ...

LRPPRC is an integral part of the post-transcriptional processing machinery required for mRNA stability, polyadenylation and translation.

Poly (A) tail length of human mitochondrial mRNAs is tissue-specific ...

The molecular basis for tissue specificity in this disease remains unknown. LRPPRC, an RNA binding protein, forms a stable complex with SLIRP, which binds to, ...

LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and ...

Moreover, LRPPRC promoted the polyadenylation of mRNAs mediated by mitochondrial poly(A) polymerase (MTPAP) in vitro. These findings provide a framework for ...

LRPPRC: A Multifunctional Protein Involved in Energy Metabolism ...

Changes in poly (A) length lead to the dysregulation of the posttranscriptional mitochondrial gene expression and pathogenic defects of respiratory chain ...

LRPPRC and SLIRP synergize to maintain sufficient and orderly ...

Moreover, the LRPPRC/SLIRP complex is required for proper loading of mt-mRNAs into mitochondrial ribosomes (mitoribosomes) (11,14). A notable ...

Structural basis of LRPPRC-SLIRP-dependent translation by the ...

Therefore, in the mitoribosome:LRPPRC-SLIRP with mRNA model, LRPPRC performs three functions: coordination of SLIRP, which plays a key role in ...

SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and ...

In mice, the LRPPRC-SLIRP complex regulates mt-mRNA stability, polyadenylation and coordinated mitochondrial translation [17]. We have also demonstrated that ...

LRPPRC-mediated folding of the mitochondrial transcriptome - Nature

Both proteins within the complex are required to regulate the rate of mitochondrial protein synthesis and the stability of the poly(A) tails of ...

Leigh Syndrome-inducing Mutations Affect LRPPRC / SLIRP ...

The LRPPRC/SLIRP complex is necessary ... LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs.

A STAT3 protein complex required for mitochondrial mRNA stability ...

The LRPPRC-SLIRP complex regulates mtRNA polyadenylation, stability, and delivery to the mitochondrial ribosome. In the absence of STAT3 mature ...

RNA binding protein: coordinated expression between the nuclear ...

The poly (A) tail length of mitochondrial mRNA is impacted by the loss of LRPPRC, which is required to preserve the untranslated polyadenylated ...

LRPPRC and SLIRP are part of an RNA-dependent... - ResearchGate

LRPPRC is known to modulate the poly(A) tail of mRNAs in mitochondria [115][116][117][118] [119] , and its dysfunction influences the efficiency of the RNA ...

A STAT3 protein complex required for mitochondrial mRNA stability ...

LRPPRC is an essential pro- tein26,29 ... LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs.