Large sequencing effort links new genes to Crohn's disease risk

An international consortium of researchers has identified 10 new genes that elevate or lower a person's risk of Crohn's disease, a form of ...

Large-scale sequencing identifies multiple genes and rare variants ...

GWAS in Crohn's Disease (CD), and inflammatory bowel disease (IBD) more generally, have successfully identified more than 200 loci contributing to risk of ...

Large-scale sequencing identifies multiple genes and rare variants ...

Genome-wide association studies (GWASs) have identified hundreds of loci associated with Crohn's disease (CD). However, as with all complex diseases, ...

Single-cell analysis of Crohn's disease reveals a detailed picture of ...

The atlas is the largest study of single cells from Crohn's patients to date, and contains the gene expression profiles of more than 700,000 ...

Xavier Lab - Center for Computational and Integrative Biology

Large scale sequencing efforts link new genes to Crohn's disease risk. To better understand the biology of Crohn's disease, the International Inflammatory ...

Genetic studies of Crohn's disease: Past, present and future

We describe on-going and future gene-mapping studies that utilise next generation sequencing technology to pinpoint causal variants and identify ...

A disease-associated gene desert directs macrophage ... - Nature

Increasing rates of autoimmune and inflammatory disease present a burgeoning threat to human health1. This is compounded by the limited ...

A systematic review and functional bioinformatics analysis of genes ...

Crohn's disease is one of the two categories of inflammatory bowel diseases that affect the gastrointestinal tract.

Common and Rare Variant Prediction and Penetrance of IBD in a ...

Background and Aims. Polygenic risk scores (PRS) may soon be used to predict inflammatory bowel disease (IBD) risk in prevention efforts. We ...

Current Developments of Clinical Sequencing and the Clinical Utility ...

Likewise, a genetic risk score incorporating all known IBD risk alleles showed strong association with disease subphenotypes (44). Predictive ...

Genetics: Clues in the code - Nature

Gene exploration is providing unexpected insights into inflammatory bowel disease, and getting scientists closer to finding treatments that target the ...

IIBDGC

... and whole exome/whole genome sequencing data for over 75,000 patients with IBD. ... effort to understand the genetic risk of IBD and its complications but ...

Identifying Crohn's disease signal from variome analysis

After years of concentrated research efforts, the exact cause of Crohn's disease (CD) remains unknown. Its accurate diagnosis, however, ...

Multi-omics in Crohn's disease: new insights from inside

The emerging multi-omics analysis based on high-throughput sequencing technology gradually visualized the complex pathogenesis and corresponding ...

778 EXOME SEQUENCING IN 30,000 CASES DEFINES NOVEL ...

To further rare variant-based discovery, we pursued large-scale exome sequencing of more than 30,000 Crohn's disease (CD) cases and population controls from ...

Inherited determinants of Crohn's disease and ulcerative colitis ...

The genetic risk score representing all known risk alleles for inflammatory bowel disease showed strong association with disease subphenotype (p ...

Whole-genome sequencing of African Americans implicates ...

Although no new loci for inflammatory bowel disease are discovered at genome-wide significance levels, we identify numerous instances of ...

(PDF) Sequencing of over 100,000 individuals identifies multiple ...

Genome-wide association studies (GWAS) have identified hundreds of loci associated with Crohns disease (CD); however, as with all complex ...

“Large-scale sequencing identifies multiple genes and rare variants ...

As product of a highly collaborative effort in the International Inflammatory Bowel Disease Consortium, “Large-scale sequencing identifies ...

Large-scale sequencing identifies multiple genes and rare variants ...

Large-scale sequence-based analyses identify novel risk variants and susceptibility genes for Crohn's disease, and implicate mesenchymal cell-mediated ...