Lateral habenula in the pathophysiology of depression

Lateral habenula in the pathophysiology of depression - PubMed

The aberrant activity of the LHb is associated with depressive symptoms such as helplessness, anhedonia, and excessive negative focus.

Lateral habenula in the pathophysiology of depression - ScienceDirect

The aberrant activity of the LHb is associated with depressive symptoms such as helplessness, anhedonia, and excessive negative focus.

A Major Role for the Lateral Habenula in Depressive Illness - Frontiers

Aberrant increases in neuronal activity in the lateral habenula, an anti-reward center, signals down-regulation of brainstem dopaminergic and ...

A Major Role for the Lateral Habenula in Depressive Illness

Aberrant increases in neuronal activity in the lateral habenula, an anti-reward center, signals down-regulation of brainstem dopaminergic and ...

Disrupted habenula function in major depression - Nature

Moreover, single-cell recording studies in non-human primates have demonstrated that the lateral habenula (LHb) responds to aversive stimuli, ...

[PDF] Lateral habenula in the pathophysiology of depression

176 Citations · The lateral habenula in depression: a mini-review · Brain circuit dysfunction in specific symptoms of depression · A Major Role for the Lateral ...

Multi-level variations of lateral habenula in depression - Frontiers

Summary schematic of neural circuits linking the lateral habenula (LHb) to the pathophysiology of depression. The circuits have experimentally proven to ...

A major role for the lateral habenula in depressive illness

Emerging preclinical and clinical evidence indicate that the lateral habenula plays a major role in the pathophysiology of depressive illness.

(PDF) Lateral habenula in the pathophysiology of depression

Depression has been suggested to be the result of maladaptive changes in specific brain circuits. Recently, the lateral habenula (LHb) has emerged as a key ...

βCaMKII in Lateral Habenula Mediates Core Symptoms of Depression

These results identify βCaMKII as a powerful regulator of LHb neuron function and a key molecular determinant of depression.

The thalamic reticular nucleus-lateral habenula circuit regulates ...

Enhanced excitatory input to the lateral habenula (LHb) has been implicated in the pathophysiology of depression. However, the contribution ...

SNORA69 is up-regulated in the lateral habenula of individuals with ...

Major depressive disorder (MDD) is a complex and potentially debilitating illness whose etiology and pathology remains unclear.

Total Recall: Lateral Habenula and Psychedelics in the Study of ...

Among the two, the lateral habenula has primarily been associated with depression, while the medial with substance use disorders [11,20,21].

Alterations of functional connectivity of the lateral habenula in ...

SD has been considered the precursor to MDD. The cluster discharge of the LHb in rats is sufficient for the occurrence of depression [19, 29, 31] ...

Lateral habenula in the pathophysiology of depression - Ex Libris

Increasing evidence from rodent, non-human primate and human studies indicates that the aberrant activity of the LHb is associated with depressive symptoms such ...

Habenula responses to potential and actual loss in major depression

Animal models of depression have supported the hypothesis that perturbations in habenula activity contribute to the pathophysiology of Major Depressive Disorder ...

Dysregulation of the Lateral Habenula in Major Depressive Disorder

The diverse neurochemical processes arising in the LHb that underscore the emergence and treatment of MDD are considered in this review, including recent ...

The lateral Habenula: Role in Chronic Pain and Depression

In recent years, the LHb has attracted great attention due to its important role in the pathogenesis of depression and pain. The LHb receives ...

Multi-level variations of lateral habenula in depression - ResearchGate

Despite extensive research in recent decades, knowledge of the pathophysiology of depression in neural circuits remains limited.

A systematic review of habenula dysfunction in depression | bioRxiv

Direct stimulation of the habenula is sufficient to induce a depressive phenotype in rodents, suggesting a causative role in depression. However ...