Ligand|Independent Epidermal Growth Factor Receptor ...

Epidermal growth factor receptor (EGFR) is a transmembrane receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ...

Biochemistry, Epidermal Growth Factor Receptor - StatPearls - NCBI

The binding of soluble EGF ligands to the extracellular domain promotes receptor activation. EGFR and ErbB4 are fully functional receptors that ...

Epidermal growth factor receptor - Wikipedia

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor ...

Ligand-Independent Epidermal Growth Factor Receptor ...

The expression of EGFR ligands was not detected in the non-neoplastic colorectal mucosa. In CRC, EGFR ligands were expressed in the cytoplasm of ...

The epidermal growth factor receptor and its ligands as therapeutic ...

Abstract. The epidermal growth factor receptor (EGFR) is detected on many non-haematopoietic tissues and is frequently overexpressed in human tumors. With its ...

Enhanced dimerization drives ligand-independent activity of mutant ...

Epidermal growth factor receptor kinase mutations drive oncogenesis, but the molecular mechanism of pathological signal initiation is poorly ...

A molecular mechanism for the generation of ligand-dependent ...

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that couples the binding of extracellular ligands, such as EGF and ...

EGFR gene: MedlinePlus Genetics

... factor receptor binds to at least seven different ligands. The binding of a ligand to epidermal growth factor receptor allows the receptor ...

Structural basis for inhibition of the epidermal growth factor receptor ...

Our structure of sEGFR in complex with the antigen binding fragment of cetuximab reveals the molecular mechanism of its inhibition of ligand-induced EGFR ...

Ligand-independent Dimer Formation of Epidermal Growth Factor ...

Dimerization and phosphorylation of the epidermal growth factor (EGF) receptor (EGFR) are the initial and essential events of EGF-induced ...

Biased signaling downstream of epidermal growth factor receptor ...

Here, we show that in contrast to primary tumors, ligand-mediated activation of EGFR in metastatic BC is dominated by STAT1 signaling. This ...

High- and Low-Affinity Epidermal Growth Factor Receptor-Ligand ...

Here we find that the high- and low-affinity interactions between EGFR and its ligands activate different signaling pathways.

Identification and characterization of a novel peptide ligand of ...

Epidermal growth factor receptor (ErbB1, EGFR) is overexpressed in a variety of human cancer cells. It has been considered as a rational ...

Ligand-induced transmembrane conformational coupling in ... - Nature

We report that ligand binding induces intracellular conformational changes within monomeric, full-length epidermal growth factor receptor (EGFR).

Stress-induced endocytosis and degradation of epidermal growth ...

Upon activation by a ligand, such as EGF, EGFR is tyrosine-phosphorylated, and subsequently recruits Cbl, an E3 ubiquitin ligase, and Grb2, an ...

Targeting Epidermal Growth Factor Receptor for Cancer Treatment

Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, is activated by ligand binding, overexpression, or mutation. It is well ...

N-Glycosylation as determinant of epidermal growth factor receptor ...

N-glycosylation is required for EGFR trafficking, efficient ligand binding, and receptor activation (12, 14–17), suggesting this modification confers an ...

Type I RTKs: ErbB (epidermal growth factor) receptor family

Other Binding Ligands; Large-scale Ligand Screening Data; Immuno Process Associations; Clinically-Relevant Mutations and Pathophysiology; Gene Expression and ...

Employment of the Epidermal Growth Factor Receptor in Growth ...

The traditional view of growth factor receptors and hormone receptors in general is that a specific ligand directly recognizes a highly selective binding s.

Extracellular domain mutations of the EGF receptor differentially ...

we analyzed the binding and biological response to the seven different EGF receptor ligands in three common glioblastoma mutants—R84K, A265V, and G574V ...