Ligand|activated epidermal growth factor receptor

Biochemistry, Epidermal Growth Factor Receptor - StatPearls - NCBI

The binding of soluble EGF ligands to the extracellular domain promotes receptor activation. EGFR and ErbB4 are fully functional receptors that ...

The epidermal growth factor receptor ligands at a glance - PubMed

The epidermal growth factor receptor (EGFR) regulates key processes of cell biology, including proliferation, survival, and differentiation during ...

Epidermal growth factor receptor - Wikipedia

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor ...

The epidermal growth factor receptor and its ligands as therapeutic ...

Abstract. The epidermal growth factor receptor (EGFR) is detected on many non-haematopoietic tissues and is frequently overexpressed in human tumors. With its ...

A molecular mechanism for the generation of ligand-dependent ...

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that couples the binding of extracellular ligands, such as EGF and ...

EGFR gene: MedlinePlus Genetics

... factor receptor binds to at least seven different ligands. The binding of a ligand to epidermal growth factor receptor allows the receptor ...

Epidermal growth factor receptor: mechanisms of activation and ...

We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the ...

The Epidermal Growth Factor Receptor Pathway: A Model for ...

EGFR becomes activated by receptor overexpression (frequent in cancer) as well as ligand-dependent and ligand-independent mechanisms. There are ...

Molecular basis for multimerization in the activation of the epidermal ...

The epidermal growth factor receptor (EGFR) is activated by dimerization, but activation also generates higher-order multimers, whose nature ...

Ligand-Independent Epidermal Growth Factor Receptor ...

The expression of EGFR ligands was not detected in the non-neoplastic colorectal mucosa. In CRC, EGFR ligands were expressed in the cytoplasm of ...

Enhanced dimerization drives ligand-independent activity of mutant ...

Epidermal growth factor receptor kinase mutations drive oncogenesis, but the molecular mechanism of pathological signal initiation is poorly ...

High- and Low-Affinity Epidermal Growth Factor Receptor-Ligand ...

Here we find that the high- and low-affinity interactions between EGFR and its ligands activate different signaling pathways.

Substrate Selectivity of Epidermal Growth Factor-Receptor Ligand ...

Abstract. Signaling via the epidermal growth factor receptor (EGFR), which has critical roles in development and diseases such as cancer, is regulated by ...

Ligand-activated epidermal growth factor receptor (EGFR) signaling ...

These results demonstrate that ligand-activated EGFR signaling controls unliganded receptors through feedback phosphorylation.

Biased signaling downstream of epidermal growth factor receptor ...

Here, we show that in contrast to primary tumors, ligand-mediated activation of EGFR in metastatic BC is dominated by STAT1 signaling. This ...

Comprehensive Model for Epidermal Growth Factor Receptor ...

The epidermal growth factor (EGF) receptor (EGFR) undergoes ligand-dependent dimerization to initiate transmembrane signaling.

Activation of the EGF Receptor by Ligand Binding and Oncogenic ...

The epidermal growth factor receptor (EGFR) plays vital roles in cellular processes including cell proliferation, survival, motility, and differentiation.

QuickGO::Term GO:0038004

EGFR ligand maturation, exact. epidermal growth factor receptor ligand processing, related. EGFR ligand processing, narrow. peptide bond cleavage involved in ...

EGF receptor ligands: recent advances - F1000Research

This focused review is meant to highlight recent studies related to actions of the individual EGFR ligands, the interesting biology that has been uncovered,

Immunodetection of the Ligand-Activated Receptor for Epidermal ...

We describe here a method to detect the activation state of Epidermal Growth Factor receptor (EGFr) with a monoclonal antibody (mAb74). This antibody was found ...