Ligand entry pathways control the chemical space recognized by ...

The G protein-coupled receptor GPR183 is a chemotactic receptor with an important function in the immune system and association with a variety of diseases.

The G protein-coupled receptor GPR183 is a chemotactic receptor with an important function in the immune system and association with a ...

Ligand entry pathways control the chemical space recognized by ...

Our work reveals that the receptor possesses two ligand entry channels: one lateral between transmembrane helices 4 and 5 facing the membrane, and one facing ...

Ligand entry pathways control the chemical space recognized by ...

Ligand entry pathways control the chemical space recognized by GPR183. / Kjær, Viktoria Madeline Skovgaard; Stępniewski, Tomasz Maciej; Medel-Lacruz, Brian; ...

Ligand entry pathways control the chemical space recognized by ...

The G protein-coupled receptor GPR183 utilizes two ligand entry channels: one lateral between transmembrane helices 4 and 5 facing the membrane, ...

Ligand entry pathways control the chemical space recognized by ...

Ligand entry pathways control the chemical space recognized by GPR183. by Viktoria Madeline Skovgaard Kjær, Tomasz Maciej Stępniewski, Brian Medel-Lacruz, ...

Ligand entry pathways control ... - Portal de la Recerca de Catalunya

Title: Ligand entry pathways control the chemical space recognized by GPR183. Authors: Kjær VMS; Stepniewski T; Medel-Lacruz B; Reinmuth L; Ciba M; ...

Supplementary Information Ligand entry pathways control the ...

Ligand entry pathways control the chemical space recognized by GPR183 ... Biological and Chemical Research Centre, Faculty of Chemistry. University of ...

Ligand entry pathways control the chemical space recognized by ...

Ligand entry pathways control the chemical space recognized by GPR183. Chem. Sci. Pub Date : 2023-09-25. DOI : 10.1039/d2sc05962b. Viktoria Madeline Skovgaard ...

Ligand entry pathways control the chemical space ... - Altmetric

In addition, we locate another entrance connecting the #GPCR binding site to the extracellular milieu and link it to the activation by less hydrophobic ...

RRIDs were included in the Chemical Science paper "Ligand entry ...

RRIDs were included in the Chemical Science paper "Ligand entry pathways control the chemical space recognized by GPR183".

Ligand entry pathways control ... - Portal de la Recerca de Catalunya

Títol: Ligand entry pathways control the chemical space recognized by GPR183. Autors: Kjær VMS, Stepniewski TM, Medel-Lacruz B, Reinmuth L, Ciba M, ...

Known GPR183 ligands and general ligand structures. A) the ...

... ligand 7a,25-OHC exhibited a LogD7.4 of >5.3. ... Ligand entry pathways control the chemical space recognized by GPR183. Article. Full-text available. Sep 2023 ...

Bitopic Ligands and Metastable Binding Sites - Europe PMC

Ligand entry pathways control the chemical space recognized by GPR183. Kjær VMS, Stępniewski TM, Medel-Lacruz B, Reinmuth L, Ciba M, Rexen Ulven E, Bonomi M ...

The pathway of ligand entry from the membrane bilayer to a lipid G ...

The binding process through the membrane bilayer of lipid-like ligands to a protein target is an important but poorly explored recognition ...

Chemical Space Expansion of Bromodomain Ligands Guided by in ...

Overall, 53 top-ranking compounds were synthesized (Scheme 1A–C) and a competition binding assay (BROMOscan) (88) was used to measure dissociation constants ( ...

Structural insights into ligand recognition by the lysophosphatidic ...

Ligand entry pathways control the chemical space recognized by GPR183. · Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand ...

The pathway of ligand entry from the membrane bilayer to a lipid G ...

The binding process through the membrane bilayer of lipid-like ligands to a protein target is an important but poorly explored recognition ...

Deciphering the Complexity of Ligand–Protein Recognition ...

Understanding the molecular interactions between ligand and protein during the approaching pathways is thus central to the deep understanding and to the ...

Data-driven classification of ligand unbinding pathways - PNAS

Studying the pathways of ligand–receptor binding is essential to understand the mechanism of target recognition by small molecules. The binding free energy ...