Lipid rafts and T|lymphocyte function

Lipid rafts and T-lymphocyte function: Implications for autoimmunity

Experimental evidence indicates that the mammalian cell membrane is compartmentalized. A structural feature that supports membrane segmentation implicates ...

Lipid rafts and T-lymphocyte function: implications for autoimmunity

A structural feature that supports membrane segmentation implicates assemblies of selected lipids broadly referred to as lipid rafts. In T- ...

Review Lipid rafts in T cell signalling and disease - ScienceDirect.com

A large number of studies report on lipid rafts having a key role in receptor signalling and activation of lymphocytes.

Lipid rafts and T-lymphocyte function: Implications for autoimmunity

In T-lymphocytes, lipid rafts are implicated in signalling from the T-cell antigen receptor (TCR) and in localization and function of proteins residing ...

Lipid rafts and T‐lymphocyte function: Implications for autoimmunity

A structural feature that supports membrane segmentation implicates assemblies of selected lipids broadly referred to as lipid rafts. In T- ...

Ordered Just So: Lipid Rafts and Lymphocyte Function - Science

Activation of signaling in lymphocytes takes place in and around specialized membrane subdomains called lipid rafts (also known as DIGs and GEMs).

Transcriptional Regulation of T-Cell Lipid Metabolism - Frontiers

Signaling molecules accumulate at high density in lipid rafts and they are essential for immune cell activation and function (5, 6). Cholesterol helps to ...

Structure and function of lipid rafts in human activated T cells

Abstract. Lipid rafts, specialized membrane microdomains enriched in sphingolipids and cholesterol, have been shown to function as signaling ...

The Functional Roles of Lipid Rafts in T Cell Activation, Immune ...

The first appearance of lipid rafts, or lipid rafts-like structure, was occasionally observed by cryo-electronic microscopy in 1980s as ...

Synthetic lipid rafts formed by cholesterol nano-patch induce T cell ...

The coalescence of small lipid rafts into a large lipid raft forms a signaling platform at the immunological synapse that plays a crucial role ...

Lipid rafts in immune signalling: current progress and future ...

Lipid rafts play a crucial role in protein sorting and receptor-mediated signal transduction, providing a distinct environment for the ...

Full article: Lipid rafts in lymphocyte activation and migration (Review)

At the plasma membrane, T cell polarization is accompanied by assemblies of specialized lipids with the characteristics of 'lipid rafts'. Under ...

CD4 and CD8 T cells require different membrane gangliosides for ...

Molecules called gangliosides are known to be major components of lipid rafts, but their role in T-cell activation has not been established. Here, we show that ...

Lipid raft-based membrane order is important for antigen-specific ...

A number of other accessory cell proteins with co-stimulatory function provide additive or synergistic signaling [27]. All these signaling ...

Role of Lipid Rafts in Pathogen-Host Interaction - A Mini Review

Lipid rafts, also known as microdomains, are important components of cell membranes and are enriched in cholesterol, glycophospholipids and receptors.

Lipid rafts and B-cell activation | Nature Reviews Immunology

Recent evidence indicates that membrane microdomains, termed lipid rafts, have a role in B-cell activation as platforms for B-cell receptor (BCR) signalling.

Visualizing Lipid Raft Dynamics and Early Signaling Events during ...

These B-cell cytonemes are rich in lipid rafts and actin filaments, suggesting that they might play a role in long-range communication and/or ...

Lipid rafts and T‐lymphocyte function: Implications for autoimmunity

A structural feature that supports membrane segmentation implicates assemblies of selected lipids broadly referred to as lipid rafts. In T‐lymphocytes, lipid ...

Lipid rafts: cell surface platforms for T cell signaling - SciELO Chile

Thus rafts are hotspots for both protein and lipid signalling pathways. Key terms: lipid rafts; Lck; tyrosine kinase; T cell; signalling; phosphatase. (*) ...

Structure and function of lipid rafts in human activated T cells

In fact,. GM3 is the major ganglioside on the plasma membrane of human peripheral blood lymphocytes and appears to play a functional role in raft-mediated T ...