Liquid–liquid phase separation of amyloid|β oligomers modulates ...

Liquid–liquid phase separation of amyloid-β oligomers modulates ...

In this study, we reported that AβOs can undergo liquid–liquid phase separation (LLPS) to form liquid-like droplets in vitro.

Liquid-liquid phase separation of amyloid-β oligomers modulates ...

Soluble amyloid-β oligomers (AβOs) are proposed to instigate and mediate the pathology of Alzheimer's disease, but the mechanisms involved ...

(PDF) Liquid-liquid phase separation of amyloid-β oligomers ...

Finally, we observed that LLPS of AβOs can further promote Aβ to form amyloid fibrils, which can be modulated by (-)-epigallocatechin gallate (EGCG). Our study ...

Liquid-liquid phase separation of amyloid-β oligomers modulates ...

Abstract. Soluble amyloid-β oligomers (AβOs) are proposed to instigate and mediate the pathology of Alzheimer's disease, but the mechanisms involved are not ...

Aggregation of the amyloid-β peptide (Aβ40) within condensates ...

Liquid-liquid phase separation of amyloid-β oligomers modulates amyloid fibrils formation. J. Biol. Chem. 299, 102926 (2023). Article CAS ...

Phase separation modulates the functional amyloid assembly of ...

Liquid-liquid phase separation of amyloid-β oligomers modulates amyloid fibrils formation. J. Biol. Chem. (2023), Article 100310, 10.1016/j.chemosphere ...

Amyloid Aggregation and Liquid-Liquid Phase Separation from the ...

A high concentration of amyloidogenic proteins in the droplets might promote the formation of toxic oligomers and increase the nucleation rates ...

Elsevier Biomedchem on X: "Liquid–liquid phase separation of ...

Liquid–liquid phase separation of amyloid-β oligomers modulates amyloid fibrils formation https://t.co/kSIW2t1HrD.

Surface-catalyzed liquid–liquid phase separation and amyloid-like ...

X. Gui, et al. Liquid–liquid phase separation of amyloid-β oligomers modulates amyloid fibrils formation. J. Biol. Chem.

Aggregation of the Amyloid-β Peptide (Aβ40) within Condensates ...

We investigated whether Aβ could undergo liquid-liquid phase separation, and whether Aβ amyloid aggregation could take place within Aβ liquid condensates.

Genetics & Genomics on X: "Liquid–liquid phase separation of ...

Liquid–liquid phase separation of amyloid-β oligomers modulates amyloid fibrils formation https://t.co/BYCbCGUSW7.

Liquid-liquid Phase Separation of Alpha-synuclein Increases the ...

et al. Liquid–liquid phase separation of amyloid-β oligomers modulates amyloid fibrils formation. J. Biol. Chem . 299, ...

Amyloid Aggregation and Liquid–Liquid Phase Separation from the ...

... Liquid–liquid phase separation of amyloid-β oligomers modulates amyloid fibrils formation. Gui X., Feng S., Li Z., Li Y., Reif B., Shi B ...

LLPS of Aβ 42 Os depends on hydrophobic interactions. A, liquid-like...

A,. Liquid-liquid phase separation of amyloid-β oligomers modulates amyloid fibrils formation. Article. Full-text available. Jan 2023. Xinrui Gui ...

Amyloid Aggregation under the Lens of Liquid–Liquid Phase ...

Increasing experiments suggest that amyloid peptides can undergo liquid–liquid phase separation (LLPS) before the formation of amyloid ...

Phase separation modulates the functional amyloid assembly of ...

Liquid-liquid phase separation of amyloid-β oligomers modulates amyloid fibrils formation. J. Biol. Chem., 100310 https://doi.org/10.1016/j ...

Liquid-Liquid Phase Separation and Its Mechanistic Role in ...

Assuming that these small oligomers are on pathway towards amyloid formation ... Phase separation can modulate protein aggregation by several ...

Phase separation modulates the functional amyloid assembly of ...

Gui, Liquid-liquid phase separation of amyloid-β oligomers modulates amyloid fibrils formation, J. ... Xing, Amyloid aggregation under the lens of liquid−liquid ...

Liquid‐liquid phase separation and fibrillation of the prion protein ...

... phase separation induced by Amyloid-β oligomers.22 Based on these ... oligomerization process, nucleate higher order assemblies, and modulate ...

Liquid-liquid phase separation induces pathogenic tau ... - Nature

Extended phase separation promoted a time-dependent adoption of toxic conformations and oligomerization, but not filamentous aggregation. P301L ...