Local IL|17 orchestrates skin aging

Local IL-17 orchestrates skin aging | bioRxiv

Strikingly, IL-17 neutralization significantly delays the appearance of age-related traits, such as decreased epidermal thickness, increased ...

Targeting lymphoid-derived IL-17 signaling to delay skin aging

Mechanistically, aberrant IL-17 signals through NF-κB in epidermal cells to impair homeostatic functions while promoting an inflammatory state.

Local IL-17 orchestrates skin aging - preLights

IL-17 blockade in aged mice improves epidermal health, thus pinpointing the physiological relevance of IL-17 skin aging.

Local IL-17 orchestrates skin aging - FoxHunt Search | Marist

We have found that increased local IL17 secreted by gamma/delta T cells, T helper 17 cells and ILCs, coordinate many of traits associated to skin aging, ...

Local IL-17 orchestrates skin aging - ResearchGate

Importantly, in vivo blockade of IL-17 signaling during aging reduces the proinflammatory state of the skin, delaying the appearance of age-related traits.

The IL-17 protein plays a key role in skin ageing - EurekAlert!

Blocking the function of IL-17 reduces the pro-inflammatory state and delays the appearance of age-related features in the skin. Published in ...

Targeting lymphoid-derived IL-17 signaling to delay skin aging

The nature of these age-associated inflammatory cues, or how they affect tissue aging, is unknown. Based on single-cell RNA sequencing of the ...

The IL-17 family in diseases: from bench to bedside - PMC - NCBI

IL-17 is a highly versatile proinflammatory cytokine necessary for vital processes including host immune defenses, tissue repair, inflammatory disease ...

Holger Heyn on X: "OUT NOW! Local IL-17 orchestrates skin aging ...

OUT NOW! Local IL-17 orchestrates skin aging. #singlecell atlas of the #aging mouse skin - showing skew towards IL17 Th cells with IL17 ...

Targeting Pro-Inflammatory Cytokine IL-17 to Slow Skin Aging

Our results show that elevated IL-17 signaling, secreted by aged dermal CD4+ T-helper cells, γδ T cells, and innate lymphoid cells, orchestrated ...

Il-17 in skin infections and homeostasis - ScienceDirect.com

IL-17 is important for epithelial barriers, including the skin, where some of its cellular targets reside. Most of the research work on IL-17 ...

IL-17 Signaling in Keratinocytes Orchestrates the Defense against ...

We conclude that deficiency of IL-17RA on KCs leads to microbiota dysbiosis in the skin, which triggers the expansion of IL-17A−producing T cells. Our data show ...

The IL-17 protein plays a key role in skin aging - ScienceDaily

A team of scientists has discovered that IL-17 protein plays a central role in skin aging. The study highlights an IL-17-mediated ageing ...

IL-17A inhibitors alleviate Psoriasis with concomitant restoration of ...

Conclusion: The psoriatic gut/skin microbiota exhibits loss of community stability and pathogen enrichment. IL-17A inhibitors restore microbiota homeostasis and ...

Wound healing in aged skin exhibits systems-level alterations in ...

Our comparative study uncovers a more pronounced inflammatory phenotype in aged skin wounds, featuring neutrophil persistence and higher abundance of an ...

(PDF) Targeting lymphoid-derived IL-17 signaling to delay skin aging

Importantly, in vivo blockade of IL-17 signaling during aging reduces the proinflammatory state of the skin, delaying the appearance of age- ...

IL-17 Protein Plays an Important Role in Skin Aging, FDA Approved ...

... IL-17 protein as a determining factor in skin ageing. Local IL-17 orchestrates skin aging. Blocking the function of IL-17 reduces the pro ...

Local IL-23 is required for proliferation and retention of skin-resident ...

Anti–IL-23 biologic-based therapies show remarkable efficacy in reducing the organ-specific TH17 inflammation of psoriasis, inflammatory ...

The metabolism-modulating activity of IL-17 signaling in health and ...

Collectively, in homeostasis and acute models of inflammation, IL-17 promotes skin and gut tissue repair rather than drives pathogenic ...

Cytokines and chemokines orchestrate atopic skin inflammation

Mechanical injury stimulates the production of primary proinflammatory cytokines (IL-1 and TNF-α), which in turn induce CCL27 and CCL17 production by ...