Local genetic correlation via knockoffs reduces confounding due to ...

Local genetic correlation analysis is an important tool for identifying genetic loci with shared biology across traits.

... Local genetic correlation via knockoffs reduces confounding due to cross-trait assortative mating,. The American Journal of Human Genetics ...

AJHG on X: " New from Ma et al. Local genetic correlation via ...

New from Ma et al. Local genetic correlation via knockoffs reduces confounding due to cross-trait assortative mating ...

Local genetic correlation via knockoffs removes confounding due to ...

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Iuliana Ionita-Laza - Homepage - Columbia University

I am particularly interested in developing statistical and machine learning methods for the analysis of high-dimensional genetic and functional genomics data. I ...

Shiyang Ma

Ma, S., Wang, F., Border, R., Buxbaum, J., Zaitlen, N. and Ionita-Laza, I. (2024) Local genetic correlation via knockoffs reduces confounding due to cross-trait ...

Identification of putative causal loci in whole-genome sequencing ...

Statistically, the knockoff filter is expected to have similar or higher power for independent tests compared with the BH procedure. For correlated genetic ...

GhostKnockoff inference empowers identification of putative causal ...

The knockoffs serve as negative controls for the conditional tests to select significant genetic risk loci and to attenuate the confounding ...

Powerful gene-based testing by integrating long-range chromatin ...

The knockoff genotypes are essentially noisy copies of the original genotypes and serve as negative controls for the original genotype data; they help to select ...

Cross-trait assortative mating is widespread and inflates genetic ...

The observation of genetic correlations between disparate traits has been interpreted as evidence of widespread pleiotropy, altered theories of ...

False discovery rate control in genome-wide association ... - PNAS

This allows the generation of imperfect copies (knockoffs) of these variables that serve as ideal negative controls, correcting for linkage disequilibrium and ...

Statistical examination of shared loci in neuropsychiatric diseases ...

Genetic correlation analysis within specific regions enables a new strategy for identifying pleiotropy. Genomic regions with significant 'local' genetic ...

Tree-based QTL mapping with expected local genetic relatedness ...

GWASs are widely and successfully used, but they face challenges related to the fact that variants are tested for association with a phenotype independently, ...

Confounding and Heterogeneity in Genetic Association Studies with ...

Although adjustment for global ancestry can control for confounding, additional adjustment for local ancestry may increase power when the ...

Mendelian imputation of parental genotypes improves estimates of ...

... confounding factors to estimates of genetic correlations. By analyzing an EA PGI, we observed a lower direct/(direct + average NTC) ratio ...

AJHG (@AJHGNews) / X

... cross-trait assortative mating. Local genetic correlation via knockoffs reduces confounding due to cross-trait assortative mating · From cell.com. 3. 5.

Population genetic considerations for using biobanks as ...

Human genetic variation is a significant contributor to phenotypic variation among individuals and populations, with single-nucleotide ...

Local genetic correlation via knockoffs removes confounding due to ...

报告题目：Local genetic correlation via knockoffs removes confounding due to cross-trait assortative mating主讲人：马诗洋副研究员（上海交通 ...

Interpreting population and family-based genome-wide association ...

We show that, contrary to common interpretation, family-based estimates of direct effects can be biased by genetic confounding.

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms ...

(B) SNP-based genetic correlations between eight disorders were depicted using an in-directed graph to reveal complex genetic relationships.