Looking beyond drivers and passengers in cancer genome ...

Cancer arises as a result of acquired changes in the DNA sequence of the genome of somatic cells. A subset of the genetic changes, ...

Abstract. Cancer arises as a result of acquired changes in the DNA sequence of the genome of somatic cells. A subset of the genetic changes, dubbed driver ...

Reviews Looking beyond drivers and passengers in cancer genome ...

In this review, we discuss the insights gained from cancer genome sequencing beyond just cataloging of the drivers and passengers, and emphasize the need to ...

Looking beyond drivers and passengers in cancer genome ...

Massive genome sequencing of thousands of tumors from all major cancer types has enabled cataloging of the so-called driver and passenger mutations, and ...

[PDF] Looking beyond drivers and passengers in cancer genome ...

Emerging findings show that mutational patterns in cancer genomes can help detect signatures of known and novel DNA damage and repair processes, ...

Looking beyond drivers and passengers in cancer genome ...

Dive into the research topics of 'Looking beyond drivers and passengers in cancer genome sequencing data'. Together they form a unique fingerprint. Sort by ...

Looking beyond drivers and passengers in cancer genome ...

Looking beyond drivers and passengers in cancer genome sequencing data. https://doi.org/10.1093/annonc/mdw677 · Full text. Journal: Annals of Oncology, 2017 ...

Passenger Mutations in More Than 2500 Cancer Genomes

We found that the aggregated impact of putative passengers provides significant predictive power—beyond common driver mutations—to distinguish ...

Passengers masquerading as cancer drivers | Nature Reviews Cancer

... gene in which it occurs is a likely cancer driver. ... Looking at these features of APOBEC3A mutagenesis across whole exome sequencing ...

soria on X: "Looking beyond drivers and passengers in cancer ...

Looking beyond drivers and passengers in cancer genome sequencing data @Annals_Oncology https://t.co/hTAWltySIw.

Signatures Beyond Oncogenic Mutations in Cell-Free DNA ... - NCBI

Looking beyond Drivers and Passengers in Cancer Genome Sequencing Data. Ann. Oncol. 28, 938–945. 10.1093/annonc/mdw677 [PubMed] [CrossRef] ...

CScape-somatic: distinguishing driver and passenger point ...

... drivers and passengers, particularly for non-coding regions of the cancer genome. ... Hence, we are interested in seeing whether a ...

The Damaging Effect of Passenger Mutations on Cancer Progression

... passenger's harm extends beyond coding regions of the genome. We further ... drivers and passenger load on cancer genomes (Supplementary Information; ref.

Providing an optimized model to detect driver genes from ... - Nature

& Ganesan, S. Looking beyond drivers and passengers in cancer genome sequencing data. Ann. Oncol. 28(5), 938–945 (2017). Article CAS ...

DNA Mutations May Not Be the Cause of Cancer

The objective behind sequencing cancer genomes is to look for driver mutations, which increase the mutation rate in the cell, leading to a more ...

Inferring subgroup-specific driver genes from heterogeneous cancer ...

S. (. 2017. ) Looking beyond drivers and passengers in cancer genome sequencing data ... The COSMIC Cancer Gene Census: describing genetic dysfunction across all ...

Impact of deleterious passenger mutations on cancer progression

Looking beyond drivers and passengers in cancer genome sequencing data. S. DeS. Ganesan. Biology, Medicine. Annals of oncology : official journal of the… 2017.

Distinguishing between driver and passenger mutations in ...

In somatic cancer genomes, delineating genuine driver mutations against a background of multiple passenger events is a challenging task.

Francesco Bertoni on X: "Looking beyond drivers and passengers in ...

Looking beyond drivers and passengers in cancer genome sequencing data https://t.co/1cNW7fEIqI.

Passenger mutations in cancer evolution - OAText

A driver gene produces driver mutations but may also produce passenger ... Looking beyond drivers and passengers in cancer genome sequencing data.