Loss Of Chromosome Y

Loss of the Y Chromosome: A Review of Molecular Mechanisms ...

It is now known that mLOY is associated with a wide variety of pathologies in men, such as cardiovascular diseases, neurodegenerative disorders, and many types ...

Loss of Y Chromosome and Bladder Cancer in Men - NCI

In men, loss of the Y chromosome in bladder cancer cells helped tumors evade the immune system and grow unchecked, a new study shows.

Y chromosome loss in cancer drives growth by evasion of ... - Nature

Loss of the Y chromosome (LOY) is observed in multiple cancer types, including 10–40% of bladder cancers1–6, but its clinical and biological ...

Loss of Y Chromosome in Men Enables Cancer to Grow

As men age, some of their cells lose the very thing that makes them biological males—the Y chromosome—and this loss hampers the body's ...

Men lose Y chromosomes as they age. It may be harming their hearts

Researchers report that when they removed the Y chromosome from male mice, the animals died earlier than their Y-carrying counterparts, likely because their ...

Y chromosome affects cancer growth | National Institutes of Health ...

As males age, some cells can lose their Y chromosome due to errors in cell division. This loss of the Y chromosome is associated with health ...

Y Chromosome Loss and Implications for Oncology - AACR Journals

Loss of the Y chromosome (LOY) detected in blood cells, termed mosaic LOY, is a common event that is related to advancing age and is associated with a ...

Loss of chromosome Y in regulatory T cells | BMC Genomics | Full Text

Mosaic loss of chromosome Y (LOY) in leukocytes is the most prevalent somatic aneuploidy in aging humans. Men with LOY have increased risks ...

Loss of chromosome Y in primary tumors - ScienceDirect.com

LOY is common in aneuploid tumors. As a small and gene-poor chromosome, Y has a relatively high chance of being lost from cells “by chance,”, ...

Rats exhibit age-related mosaic loss of chromosome Y - Nature

Mosaic loss of the Y chromosome (LOY) is the most frequent chromosomal aberration in aging men and is strongly correlated with mortality and ...

Genomic alterations in patients with somatic loss of the Y ...

Loss of the Y chromosome (LOY) is one of the most common somatic genomic alterations in hematopoietic cells in men. However, due to the high ...

Men are slowly losing their Y chromosome - La Trobe University

The human Y chromosome is degenerating and may disappear in a few million years, leading to our extinction unless we evolve a new sex gene.

Loss of Chromosome Y and Its Potential Applications as Biomarker ...

Abstract. Loss of chromosome Y (LOY) is a mosaic aneuploidy that can be detected mainly in blood samples of male individuals. Usually, LOY ...

Chromosome Y loss and drivers of clonal hematopoiesis in ...

LOY in blood has been linked with an increased risk of a continuously growing list of diseases, such as various forms of hematologic and non-hematologic cancer.

Hematopoietic loss of Y chromosome leads to cardiac fibrosis and ...

Recently, a mouse model was constructed and published in Science (2) showing cardiac dysfunction and increased mortality after depletion of the ...

Mosaic loss of chromosome Y - Wikipedia

Mosaic loss of chromosome Y ... Mosaic loss of chromosome Y (mLOY) also known as loss of chromosome Y (LOY) occurs to many men in some cells due to aging. Instead ...

The Relationship Between Y Chromosome Loss & Heart Failure

UVA Health research has implicated Y chromosome loss as a factor in the development of heart disease in men.

Mosaic loss of the Y chromosome and men's health - Fukami - 2022

MLOY has been associated with early death, cancers, and other disorders in elderly men, infertility in reproductive-aged men, and developmental defects in ...

Mosaic Loss of Chromosome Y Is Associated With Functional ...

We observed an association between LOY and poor outcome after ischemic stroke in patients not receiving recanalization therapy.

Mosaic loss of Y chromosome is associated with aging and ...

Mosaic loss of Y chromosome (LOY) is the most common chromosomal alteration in aging men. Here, we use single-cell RNA and ATAC sequencing ...