Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model ...

EphA4 is a receptor of the Eph-ephrin system, which plays an important role in axon guidance during development. Previously, we identified EphA4 as a ...

EphA4 is a receptor of the Eph-ephrin system, which plays an important role in axon guidance during development.

Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model ...

Moreover, loss of EphA4 rescued the motor axon phenotype in a zebrafish model of spinal muscular atrophy (SMA). Similar to ALS, SMA is a neurodegenerative ...

SMA Motor Function in Mice Does Not Improve With EphA4 Loss ...

The study, “Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy,” was published in Frontiers in Neuroscience. EphA4 ...

Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model ...

Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy · Lindsay Poppe · Silke Smolders · Laura Rué · Mieke Timmers · Annette ...

Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model ...

Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy. Poppe, L., Smolders, S., Rue, L., Timmers, ...

Antisense-mediated reduction of EphA4 in the adult CNS does not ...

In contrast, lowering of EphA4 in the CNS of two mouse models of ALS (SOD1G93A and PFN1G118V) did not improve their motor function or survival. Furthermore ...

Decreased signalling of EphA4 improves functional performance ...

Conditional knockout of the EphA4 gene in SOD1G93A mice improved functional performance, delayed disease onset, but did not affect survival. (A) ...

Blockade of EphA4 signaling ameliorates hippocampal synaptic ...

In conclusion, the present findings provide evidence that EphA4 is critical for mediating the impairment of synaptic plasticity in AD mouse models. Further ...

https://www.frontiersin.org/journals/neuroscience/articles/10.3389 ...

No use, distribution or reproduction is permitted which does not ... mouse model for severe SMA. ... Our data suggest that either lowering EphA4 has ...

EphA4 loss improves social memory performance and alters ...

Loss of EphA4 improved social memory in a mouse model of Alzheimer's disease in association with alterations in spine morphology.

Decrease of EphA4 does not alter motor function and survival in ...

... Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy | EphA4 is a receptor of the Eph-ephrin system, which plays ...

EphA4 targeting agents protect motor neurons from cell death ...

Newer generation and more potent EphA4 agonistic agents 150D4, 150E8, and 150E7 provided effective protection at a lower therapeutic dose.

Inhibition of EphA4 reduces vasogenic edema after experimental ...

Here, we analyzed the proteomic profiles of the cultured mouse BMECs during oxygen-glucose deprivation and reperfusion (OGD/R). Besides the ...

Citations to Plastin-3 extends survival and reduces ... - JCI Insight

2019 · Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy L Poppe, S Smolders, L Rué, M Timmers, A ...

Role of EphA4 in Mediating Motor Neuron Death in MND - MDPI

EphA4 belongs to the A subgroup of Eph receptors and is well known as a pan-receptor that can widely bind, albeit with varying affinities, to all ephrin ligands ...

Exploration of the role of EphA4 in neurodegenerative diseases.

We have shown that loss of EphA4 did not improve the disease in a mouse model for severe SMA, while a similar strategy could partially improve ...

WO2012156351A1 - Epha4 is a disease modifier in motor neuron ...

Resistent motor neurons in late-symptomatic SOD1G93A mice have lower EphA4 levels. EphA4 expression in ventral horn (motor) neurons in the lumbal spinal cord of ...

[PDF] EphA4 Receptor Tyrosine Kinase Is a Modulator of Onset and ...

Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy · Lindsay PoppeSilke Smolders +9 authors. R. Lemmens. Medicine ...

EphA4 Monoclonal Antibody (4C8H5) (37-1600)

EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer's disease ...