Lysophospholipids and their G protein‐coupled receptors in biology ...

Lysophospholipids and their G protein-coupled receptors in ...

Most of the biological effects of LPLs are mediated by GPCRs. In 1996, the first LPL-GPCR was identified and shown to be LPA receptor (15). Until now, more than ...

Lysophospholipids and their G protein-coupled receptors ... - PubMed

Lysophospholipids and their G protein-coupled receptors in biology and diseases. J Cell Biochem. 2004 Aug 1;92(5):867-8. doi: 10.1002/jcb.20186. Authors.

Lysophospholipids and their G protein‐coupled receptors in biology ...

The following set of Prospects is dedicated to bioactive lysophospholipids (LPLs) and their G protein‐coupled receptors (GPCRs), ...

Lysophospholipid G Protein-coupled Receptors

The many biological responses documented for lysophospholipids that include lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically ...

Lysophospholipids and Their G-Coupled Protein Signaling in ...

G-Coupled Protein Receptors (GPCRs) of LPA and S1P in The Cell Signaling. Both LPA and S1P are cell membrane-derived bioactive LPLs. They function via the 7 ...

Lysophospholipids and their G protein-coupled receptors in ...

They play a major role as extracellular mediators by activating G-protein coupled receptors (GPCRs) and stimulating diverse cellular responses ...

Review Lysophospholipids and their G protein-coupled receptors in ...

Lysophospholipids have the capacity to evoke and modulate immune responses by attracting and activating T-cells, B-cells and macrophages directly and ...

Differential activation mechanisms of lipid GPCRs by ... - Nature

Lysophospholipids are bioactive lipids and can signal through G-protein-coupled receptors (GPCRs). The best studied lysophospholipids are ...

[PDF] Lysophospholipids and their G protein-coupled receptors in ...

The pathophysiological effects of different lysophospholipids on atherosclerosis, which may promote the pathogenesis of myocardial infarction and strokes, ...

Novel lysophosphoplipid receptors: their structure and function

It is now accepted that lysophospholipids (LysoGPs) have a wide variety of functions as lipid mediators that are exerted through G protein-coupled receptors ...

(PDF) Lysophospholipid G Protein-coupled Receptors - ResearchGate

The many biological responses documented for lysophospholipids that include lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically ...

Lysophospholipid Receptors - Sigma-Aldrich

Thus, the identification of a set of LPA/S1P G protein-coupled receptors, referred to as the â Edgâ cluster (Endothelial differentiation gene), was a seminal ...

Current Knowledge on the Biology of Lysophosphatidylserine as an ...

Lysophosphatidylserine (LysoPS) is an emerging lysophospholipid (LPL) mediator, which acts through G protein-coupled receptors, like lysophosphatidic acid (LPA ...

Towards selective lysophospholipid GPCR modulators - Cell Press

G-protein-coupled receptors (GPCRs) that recognize the lysophospholipids (LPLs) are grouped into two phylogenetically distinct families: the ...

Lysophospholipid Receptors: Signaling and Biology - Annual Reviews

... G protein-coupled receptors has provided a mechanistic framework for understanding how LPs play such diverse roles. Generation of LP receptor ...

Lysophospholipid G protein-coupled receptor binding parameters as ...

These results demonstrate that BSI may have particular utility in assessing binding interactions between lipid receptors and their lipid ligands and could ...

Lysophospholipid G Protein-coupled Receptors*

Biological roles, null muta- tions, and its relationship to the other LPA receptors have not been reported. S1P GPCRs. There are five identified ...

'Crystal' Clear? Lysophospholipid Receptor Structure Insights and ...

As major regulators of mammalian physiology, G protein-coupled receptors (GPCRs) for the structurally related lysophospholipids (LPLs) sphingosine 1-phosphate ( ...

development of agonists and antagonists for LPA and S1P receptors

Recently, lysophospholipid GPCR genes have been used to develop receptor subtype-selective agonists and antagonists. The discovery of FTY720, a ...

The Edg family G protein-coupled receptors for lysophospholipids ...

The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities. ... Biology, Chemistry, Medicine.