Lysophospholipids in the regulation of endothelial barrier function

Lysophospholipids in the regulation of endothelial barrier function ... Am J Physiol Lung Cell Mol Physiol. 2001 Dec;281(6):L1335-6. doi: 10.1152/ajplung.2001.281 ...

LPA and S1P appear to promote endothelial barrier restrictiveness (1, 4, 10), a surprising property in light of their proinflammatory and angiogenic actions.

Lysophospholipids in the regulation of endothelial barrier function

With the exception of PAF, the regulation of endo- thelial barrier function by these lipid mediators is not well known. LPA and S1P appear to promote endothe-.

Lysophosphatidic Acid Regulates Endothelial Barrier Integrity - NCBI

The role of intracellular LPA in the regulation of EC barrier integrity has not been reported. Most studies regarding the effect of LPA on EC ...

Regulation of blood and vascular cell function by bioactive ...

Abstract · Keywords · Introduction · Generation of lysophospholipids in the circulation · Metabolism of lysophospholipids in circulation · Regulation of endothelial ...

Lysophospholipids in the regulation of endothelial barrier function

Download Citation | On Jan 1, 2002, Hazel Lum published Lysophospholipids in the regulation of endothelial barrier function | Find, read and cite all the ...

Review Emerging roles of lysophospholipids in health and disease

The physiological roles of LPC are recently illuminated via the characterizations of Mfsd2a, an LPC transporter at the blood brain barrier (BBB). Mfsd2a is ...

Lysophospholipid receptors: Signalling, pharmacology and ...

Lysophospholipid GPCRs regulate a broad range of cellular functions: cell proliferation and survival, migration and chemotaxis, cytoskeletal architecture, cell- ...

Tipping the gatekeeper: S1P regulation of endothelial barrier function

The lysophospholipid sphingosine 1-phosphate (S1P) is a pleiotropic signaling lipid present constitutively in plasma, and secreted locally at elevated ...

Endothelial lipid phosphate phosphatase-3 deficiency that disrupts ...

Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development · 2.1 Materials ...

Oxidized Phospholipids in Control of Endothelial Barrier Function

OxPLs play a dual role in regulating endothelial function: some species of OxPLs have been involved in enhancing endothelial barrier integrity while others ...

Lysophosphatidic Acid Regulates Endothelial Barrier Integrity - OUCI

Tennant M, McGeachie JK. Blood vessel structure and function: a brief update on recent advances. Aust N Z J Surg. 1990;60(10):747–53.

Involvement of Lysophospholipids in Pulmonary Vascular Functions ...

In addition to these effects, the expression of the adhesion molecules is enhanced by these extracellular lysophospholipids in pulmonary endothelial cells.

Lysophospholipid receptors: Signalling, pharmacology and ... - CORE

Hla, FTY720: sphingosine-1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function, Am. J. Transp. 4 (2004) 1019–1025. [22] ...

Sphingosine-1-phosphate and its receptors in vascular endothelial ...

One of the regulators of endothelial barrier function and integrity is sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite secreted into the ...

S1P control of endothelial integrity. - Abstract - Europe PMC

Sphingosine 1-phosphate (S1P), a lipid mediator produced by sphingolipid metabolism, promotes endothelial cell spreading, vascular maturation/stabilization, ...

Lysophospholipids - SpringerLink

In summary, the lysophospholipids are local mediators that regulate development, tissue regeneration and homoeostasis, but also play a role in inflammation, ...

FTY720: Sphingosine 1-Phosphate Receptor-1 in the Control of ...

... Control of Lymphocyte Egress and Endothelial Barrier Function. Volker ... lysophospholipid receptor S1P3: role of HDL-associated lysophospholipids. J ...

Lysolipids in Vascular Development, Biology, and Disease

However, lysophospholipids also function as ligands for G-protein–coupled receptors that influence embryonic development, postnatal physiology, ...

The role of sphingolipids in endothelial barrier function - De Gruyter

Two particular sphingolipid species, sphingosine-1-phosphate and ceramide, and their metabolites interact both directly and indirectly with endothelial cells to ...