MACC1|induced migration in tumors

MACC1-induced migration in tumors: Current state and perspective

Malignant tumors are still a global, heavy health burden. Many tumor types cannot be treated curatively, underlining the need for new ...

MACC1-induced migration in tumors: Current state and perspective

This review aims to summarize the different downstream effects of MACC1 on tumor migration and how these can be integrated into the cytoskeletal and adhesive ...

MACC1-induced migration in tumors: Current state and perspective

In the few years since its discovery, MACC1 has been demonstrated to be a very promising predictive biomarker in a multitude of tumor entities because it ...

MACC1-Induced Collective Migration Is Promoted by Proliferation…

High metastasis-associated in colon cancer 1 (MACC1) expression is associated with metastasis, tumor cell migration, and increased ...

MACC1 promotes pancreatic cancer metastasis by interacting with ...

... cancer cell migration and invasion in a MET proto-oncogene receptor tyrosine kinase (MET)-independent manner. Notably, knockdown of MACC1 in ...

MACC1-Induced Collective Migration Is Promoted by Proliferation ...

Metastasis-associated in colon cancer 1 (MACC1) is a marker for metastasis, tumor cell migration, and increased proliferation in colorectal cancer (CRC).

MACC1 driven alterations in cellular biomechanics facilitate cell ...

Metastasis-associated in colon cancer 1 (MACC1) is an established marker for metastasis and tumor cell migration in a multitude of tumor ...

MACC1 mediates acetylcholine-induced invasion and migration by ...

Ours is the first observation that the oncogene MACC1 functions as a downstream signal for ACh, which acted via M3Rs to promote MACC1 expression ...

MACC1-induced migration in tumors: Current state and perspective

In recent years, metastasis associated in colon cancer 1 (MACC1) was identified as a promising biomarker and drug target, as it is promoting tumor migration, ...

MicroRNA-143 Targets MACC1 to Inhibit Cell Invasion and ...

Metastasis-associated in colon cancer-1 (MACC1) has been newly identified to express highly in colorectal cancer (CRC) and promote tumor ...

The newly identified MEK1 tyrosine phosphorylation target MACC1 ...

Here we report for the first time the ability of clinically relevant MEK1 inhibitors to restrict MACC1-induced cell migration, tumor growth, and ...

MACC1 induces autophagy to regulate proliferation, apoptosis ...

Metastasis-associated colon cancer-1 (MACC1) plays an important role in cancer development, but the role and mechansim of MACC1 in squamous cell ...

Saffron Crudes and Compounds Restrict MACC1-Dependent Cell ...

Elevated expression of this gene increases proliferation, migration, and invasiveness of cancer cells. MACC1 promotes epithelial-mesenchymal transition (EMT), a ...

MACC1 is post-transcriptionally regulated by miR-218 in colorectal ...

MACC1 induces the crucial step of carcinogenesis transition from adenoma to carcinoma in mice and human [2, 3]. In CRC and its prime ...

Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

The ablation of this specialized cell type remarkably reduced angiogenesis in the tumor and caused its regression (De Palma et al., 2005).

Confined migration promotes cancer metastasis through resistance ...

Here, we show in vitro that migrating breast cancer cells develop resistance to anoikis following their passage through microporous membranes ...

MACC1 Induces Tumor Progression in Transgenic Mice and ...

The gene MACC1 is an established biomarker for metastasis and survival in colorectal cancer patients. Here, we provide first evidence that MACC1-induced tumor ...

Plasticity of cancer cell invasion: Patterns and mechanisms

Twist1-induced EMT drives single cell invasion in carcinoma cells by activating its downstream effector, ZEB1, which requires activation of TGF-beta type-I ...

MACC1-induced collective migration is promoted by proliferation ...

Tumors with high MACC1 expression show a worse prognosis and higher invasion into neighboring structures. Yet, many facets of the pro-migratory ...

MACC1 induces metastasis in ovarian carcinoma by upregulating ...

These results demonstrated that the attenuation of MACC1 suppresses cell invasion and migration and that MACC1 may regulate cell metastasis ...