MRE11|RAD50|NBS1 complex alterations and DNA damage ...

MRE11-RAD50-NBS1 complex alterations and DNA damage ...

Here, we summarized the recent research findings of the role of MRE11-RAD50-NBS1 complex in tumorigenesis, cancer treatment and discussed the potential ...

MRE11-RAD50-NBS1 Complex Dictates DNA Repair Independent ...

Here, we show that the DSB-induced signaling cascade and homologous recombination (HR)-mediated DSB repair pathway can be genetically separated. We demonstrate ...

MRE11-RAD50-NBS1 complex alterations and DNA damage ...

This feature of malignant cells opens new avenues for tumor targeted therapy. MRE11-RAD50-NBS1 complex plays a crucial role in sensing and repair of DNA damage.

(PDF) MRE11-RAD50-NBS1 complex alterations and DNA damage ...

MRE11, the core of the MRE11/RAD50/NBS1 complex, is one of key DNA damage response proteins. Increasing evidence suggests that its expression in cancer cells is ...

Untangling the clinicopathological significance of MRE11-RAD50 ...

MRN is required not only for processing DNA damage but also for oncogene-induced replication stress. MRN is a hexameric complex consisting of ...

The MRE11 complex: A versatile toolkit for the repair of broken DNA

The MRE11 nuclease, together with RAD50 and NBS1 forms a complex termed MRN that participates in all these processes. Although MRE11 was first identified more ...

Mre11-Rad50 oligomerization promotes DNA double-strand break ...

We demonstrate that Mre11-Rad50-Xrs2 oligomerization facilitates foci formation, DNA damage signaling, repair, and telomere maintenance in vivo.

Aberrations of the MRE11–RAD50–NBS1 DNA damage sensor ...

The MRE11, RAD50, and NBS1 genes encode proteins of the MRE11–RAD50–NBS1 (MRN) complex critical for proper maintenance of genomic integrity ...

Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the ...

The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at ...

A Survey of Reported Disease-Related Mutations in the MRE11 ...

The MRE11-RAD50-NBS1 (MRN) protein complex is one of the primary vehicles for repairing DNA double strand breaks and maintaining the genomic stability ...

MRE11-RAD50-NBS1 complex alterations and DNA - ProQuest

Genome instability is a hallmark of cancer cells and can be accelerated by defects in cellular responses to DNA damage. This feature of malignant cells ...

Mre11–Rad50: the DNA end game | Biochemical Society Transactions

The Mre11–Rad50-(Nbs1/Xrs2) complex is an evolutionarily conserved factor for the repair of DNA double-strand breaks and other DNA termini in all kingdoms of ...

Post-Translational Modification of MRE11: Its Implication in DDR ...

Meiotic recombination 11 (MRE11), the key components of the MRE11-RAD50-NBS1 (MRN) complex which function mainly to activate ATM- or ATR-mediated DNA damage ...

MRE11-RAD50-NBS1 complex alterations and DNA damage ...

MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment Available Online. Send to. Print. Citation. EndNote. EasyBib.

The MRN complex: coordinating and mediating the response to ...

The MRE11–RAD50–NBS1 (MRN) protein complex has been linked to many DNA metabolic events that involve DNA double‐stranded breaks (DSBs).

MRE11-RAD50-NBS1 complex alterations and DNA damage ... - OUCI

AbstractGenome instability is a hallmark of cancer cells and can be accelerated by defects in cellular responses to DNA damage. This feature of malignant ...

Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair ...

To organize the MRN complex, the Mre11 exonuclease directly binds Nbs1, DNA, and Rad50. Rad50, a structural maintenance of chromosome (SMC) related protein, ...

MRE11-RAD50-NBS1 complex alterations and DNA damage ... - Gale

Genome instability is a hallmark of cancer cells and can be accelerated by defects in cellular responses to DNA damage.

The Mre11/Rad50/Nbs1 Complex and Its Role as a DNA Double ...

be triggered by changes in chromatin structure. THE FUNCTIONAL ... NBS1 complex DNA repair activity. J Biol Chem 2001; 276:12-5. 26. Lee JH ...

MRN complex - Wikipedia

The MRN complex also participates in activating the checkpoint kinase ATM in response to DNA damage. ... Production of short single-strand oligonucleotides by ...