Macrophage derived TNFα promotes hepatic reprogramming to ...

Hepatic macrophages, Kupffer cells, were able to induce Warburg-like metabolism in hepatocytes in vitro via TNFα. Eliminating macrophages in ...

Hepatic macrophages, Kupffer cells, were able to induce Warburg-like metabolism in hepatocytes in vitro via TNFα. Eliminating macrophages in vivo or blocking ...

Macrophage derived TNFα promotes hepatic reprogramming to ...

Macrophage derived TNFα promotes hepatic reprogramming to Warburg-like metabolism. Tatyana N Tarasenko, Maxim Jestin, Shingo Matsumoto, Keita Saito, Sean ...

Macrophage derived TNFα promotes hepatic reprogramming to ...

It is suggested that macrophages, as early sensors of pathogens, instruct hepatocytes via TNFα to undergo metabolic reprogramming to cope with challenges to ...

Macrophage derived TNFα promotes hepatic reprogramming to ...

During infection, hepatocytes must undergo a reprioritization of metabolism, termed metabolic reprogramming. Hepatic metabolic reprogramming.

Macrophage derived TNFα promotes hepatic reprogramming to ...

Request PDF | Macrophage derived TNFα promotes hepatic reprogramming to Warburg-like metabolism | During infection, hepatocytes must undergo a ...

Harnessing metabolism of hepatic macrophages to aid liver ... - Nature

Following toxicity-induced damage or physical resection, Kupffer cells as well as monocyte-derived macrophages can be activated and promote an ...

Macrophage derived TNFα promotes hepatic reprogramming to ...

Macrophage derived TNFα promotes hepatic reprogramming to Warburg-like metabolism ... Authors: Tatyana N. Tarasenko; Maxim Jestin; Shingo Matsumoto; Keita Saito ...

Hepatic macrophages in liver homeostasis and diseases-diversity ...

Necroptotic KCs release IL-1β,, which induces IL-33 production by hepatocytes. IL-33, together with basophil-derived IL-4, promotes alternative ...

Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of ...

Currently, liver organoids can be generated readily in vitro from bile-duct epithelial cells, but not hepatocytes. Here, we show that TNFα, an ...

Macrophage Polarization and Its Role in Liver Disease - Frontiers

Recently, a variety of drugs have been shown to inhibit M1 macrophage polarization by inhibiting the TLR4/NF-κB signaling pathway. For example, berberine could ...

The Role of Immune Cells in Liver Regeneration - MDPI

Upon concanavalin A (ConA) treatment, monocyte-derived macrophages are rapidly recruited to encapsulate necrotic lesions and induce death- ...

Monocyte-derived macrophages orchestrate multiple cell-type ... - JCI

MoMFs play an important role in inducing the formation of an aHSC layer and promote necrotic area resolution. To determine whether the expansion ...

Hepatic Macrophage as a Key Player in Fatty Liver Disease - Frontiers

Hepatic macrophages promote neutrophil adhesion to liver sinusoidal endothelial cells (LSECs) via TLR4 (65) and increase neutrophil recruitment via chemokines, ...

A macrophage-hepatocyte glucocorticoid receptor axis coordinates ...

Mechanistically, macrophage GR suppressed the expression of tumor necrosis factor (TNF) and promoted nuclear translocation of hepatocyte GR to ...

Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis ...

Mechanistically, progranulin (PGRN) appears to mediate ADAR1 deficiency-induced liver pathology, promoting interferon signaling and attracting epidermal growth ...

Macrophages and hepatocellular carcinoma - Cell & Bioscience

The tumor microenvironment promotes to HCC cells to acquire abnormal phenotypes and recruits immune cells (macrophages, T cells) [9, 10]. Tumor- ...

The Role of Tumor Associated Macrophages in Hepatocellular ...

Chronic inflammation, in turn, leads to continuous cycles of destruction-regeneration in the liver, contributing to HCC development and progression. Tumor ...

Macrophage-derived thrombospondin 1 promotes obesity ...

However, myeloid/macrophage-specific TSP1 deficiency protects mice from obesity-associated liver inflammation and fibrosis. This study provides ...

Role of Exosomal Modulation of Macrophages in Liver Fibrosis

Hepatocytes-derived exosomes. Damaged hepatocytes contribute to the progression of hepatic fibrosis by releasing signals to stimulate macrophage ...