Making Potent CAR T Cells Using Genetic Engineering and ...

Immunotherapies are emerging as powerful weapons for the treatment of malignancies. Chimeric antigen receptor (CAR)-engineered T cells have ...

In this review, I summarized the current studies regarding genetic engineering of CAR and synergistic agents to enhance the CAR T cell efficacy both in ...

Engineering the next-generation of CAR T-cells with CRISPR-Cas9 ...

This review evaluates several of the ongoing and future directions of combining next-generation CRISPR-Cas9 gene editing with synthetic biology to optimize CAR ...

Using a molecular scissors to improve CAR-T cell therapy

CAR-T cell therapy is a regenerative immunotherapy in which a person's T cells are collected from the body and genetically modified in the lab ...

Clinical manufacturing of CAR T cells: foundation of a promising ...

The treatment of cancer patients with autologous T cells expressing a chimeric antigen receptor (CAR) is one of the most promising adoptive cellular therapy ...

Potential solutions for manufacture of CAR T cells in cancer ... - Nature

CAR T cell therapy is an effective cancer treatment, but biological and manufacturing hurdles hamper its broad breakthrough.

Engineering enhanced chimeric antigen receptor-T cell therapy for ...

Synthetic biology-based genetic circuits offer a tunable approach, which overcomes the shortcomings of irreversible genetic alteration of a single gene and ...

Engineering CAR T-Cell Therapy to Overcome Limitations - NCI

Since 2017, six CAR T-cell therapies have been approved by the Food and Drug Administration, all for the treatment of blood cancers. To make CAR ...

Making Potent CAR T Cells Using Genetic Engineering and ...

At present, technology to improve CAR T cell therapy is rapidly developing. In this review, we particularly emphasize the most recent studies utilizing genetic ...

Genetically engineered T cells for cancer immunotherapy - Nature

T cells genetically equipped with chimeric antigen receptors (CARs) or TCRs have shown remarkable effectiveness in treating some hematological malignancies.

Genetic Modification Strategies to Enhance CAR T Cell Persistence ...

In addition to modifying costimulatory domains, genetic modification can be used to endow CAR T cells with the ability to express stimulatory ...

Advances in CAR-T Cell Genetic Engineering Strategies ... - Frontiers

During this last decade, adoptive transfer of T lymphocytes genetically modified to express chimeric antigen receptors (CARs) emerged as a valuable therapeutic ...

Gene modification strategies for next-generation CAR T cells against ...

In this review, we summarize innovative strategies to enhance CAR T cell function by improving target identification, persistence, trafficking, and overcoming ...

Review Engineering and Design of Chimeric Antigen Receptors

T cells engineered with chimeric antigen receptors (CARs) have emerged as a potent new class of therapeutics for cancer, based on their remarkable potency in ...

Delivery technologies for T cell gene editing: Applications in cancer ...

While initial approaches to adoptive T cell therapy relied on the identification and expansion of rare tumour-reactive T cells, genetic ...

Revolutionizing CAR T-Cell Therapies: Innovations in Genetic ...

To address these issues, various genetic engineering strategies have been proposed. Approaches such as overexpression of transcription factors or metabolic ...

Direct in vivo CAR T cell engineering

Adoptive cell therapy using chimeric antigen receptor (CAR) T cells is effective against B cell malignancies; however, the complex manufacturing ...

CAR T Cells Engineered to Prevent Antigen Escape

Figure 1. CAR T-cell therapy of cancer. T cells harvested from a patient are engineered with a vector to insert the CAR gene into the genome of ...

of Genetically Engineered CAR-T Cells Using Bifunctional Small ...

Chimeric antigen receptor (CAR)-engineered T cells (CAR-Ts) provide a potent antitumor response and have become a promising treatment option ...

Clinical Lessons from Chimeric Antigen Receptor-T Cells

T cell modification with genes that encode chimeric antigen receptors (CAR-T cells) has shown tremendous promise for the treatment of B cell ...