Mapping Cancer Drug Resistance Mutations and Mechanisms

The map uncovered insights into the mechanisms of drug resistance, highlighting DNA changes that may be potential treatment biomarkers, and identifying ...

Genetic mapping study uncovers four main categories of cancer ...

All cancer mutations that cause drug resistance fall into one of four categories. New research has detailed each type, helping to uncover targets for drug ...

Cancer drug resistance causes and categories identified - EMBL-EBI

Using CRISPR gene editing and single-cell genomic techniques, the study mapped the genetic landscape of drug resistance in cancers such as colon ...

Base editing screens define the genetic landscape of cancer drug ...

Here we prospectively identify genetic mechanisms of resistance to ten oncology drugs from CRISPR base editing mutagenesis screens in four cancer cell lines.

DRMref: comprehensive reference map of drug resistance ...

DRMref: comprehensive reference map of drug resistance mechanisms in human cancer ... Z. KinaseMD: kinase mutations and drug response database .

Mapping the pathways of resistance to targeted therapies - PMC

... mechanisms of drug resistance. These approaches ... Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.

Mapping and categorizing cancer drug resistance mechanisms

Starting with a study of how mutations affect sensitivity to 10 molecularly targeted drugs, researchers have laid the foundations for a ...

Scientists map cancer mutations in EGFR gene, revealing drug ...

... tumor growth and mechanisms of drug resistance. Background. Despite advances in genome sequencing, several genetic variants remain classified ...

Mapping Cancer's Drug Resistance To Design Better Treatment ...

... resistance mechanisms and suggest optimal drug doses and combinations across cancer types. The study, published Oct. 23 in Cell Systems ...

Unveiling the mechanisms and challenges of cancer drug resistance

Intrinsic factors include pre-existing genetic mutations, tumor heterogeneity, and activation of intracellular defense pathways, that confer ...

Mapping kinase domain resistance mechanisms for the MET ...

Mutations in the kinase and juxtamembrane domains of the MET Receptor Tyrosine Kinase are responsible for oncogenesis in various cancers and can ...

Predicting Anticancer Drug Resistance Mediated by Mutations - PMC

... mechanisms of cancer drug resistance. Keywords: cancer drug, drug resistance, single amino acid variation, protein structure, machine learning, feature ...

Mapping kinase domain resistance mechanisms for the MET ... - eLife

Mutations in the kinase and juxtamembrane domains of the MET Receptor Tyrosine Kinase are responsible for oncogenesis in various cancers and can ...

CancerDR: Cancer Drug Resistance Database | Scientific Reports

... drug seems much higher than the drugs tested randomly. In order to facilitate users to identify mutations in drug targets, NGS mapping tool ...

Role of functional genomics in identifying cancer drug resistance ...

Acquired resistance mechanisms (ARMs). The ARMs are new mutations in cancer cells that develop acquired drug resistance, leading to cancer ...

Timing and heterogeneity of mutations associated with drug ... - PNAS

The immediate effect is a dramatic reduction in disease burden, but in most cases, the tumor returns as a consequence of resistance. Various mechanisms for the ...

Drug Resistance in Cancer: An Overview - MDPI

... cancers on a compensatory repair mechanism. Dysregulation or impairment of certain DDR genes and mechanisms either by mutations or epigenetic silencing are ...

DRMref: comprehensive reference map of drug resistance ...

(2021) KinaseMD: kinase mutations and drug response ... tumor heterogeneity and drug resistance mechanisms in lung cancer targeted therapy.

Mapping genetic interactions in cancer: a road to rational ...

Moreover, therapy-resistance mechanisms in tumor cells rely on compensatory pathways that functionally buffer the inhibition of drug target ...

Cancer Drug Resistance - OAE Publishing Inc.

Cancer Drug Resistance is a peer-reviewed journal led by Editor-in-Chief Godefridus J. (Frits) Peters, covering drug resistance research on breast cancer, ...