Mapping physical networks to functional networks in SCN oscillation

Mathematical modeling suggested that a gradient in how strongly neurons are connected can explain the observed gradient in phaseoid activity.

Functional network inference of the suprachiasmatic nucleus - NCBI

Although the intracellular genetic oscillator and intercellular biochemical coupling mechanisms have been examined previously, the network ...

Functional network inference of the suprachiasmatic nucleus - PNAS

We show that hubs of this small-world network are preferentially located in the central SCN, with sparsely connected shells surrounding these cores. Finally, we ...

Pauls Lab - Dartmouth College Mathematics

Pauls Lab. Mapping physical networks to functional networks in SCN oscillation. About the Pauls Lab. The suprachiasmatic nucleus (SCN) is a cluster of roughly ...

Suprachiasmatic Nucleus: Cell Autonomy and Network Properties

In the intact SCN, cellular oscillations are synchronized and reinforced by rhythmic synaptic input from other cells, resulting in a reproducible topographic ...

Network inference from oscillatory signals based on circle map - arXiv

... physical, biological, chemical, engineering, and social systems [1] . ... SCN. Finally, we conclude this paper and discuss ... function, such that the ...

GABA Networks Destabilize Genetic Oscillations in the Circadian ...

Spike trains from SCN neurons were recorded using MEAs and the Z score and strength of each interaction was measured. We graphed functional ...

Network-driven intracellular cAMP coordinates circadian rhythm in ...

Thus, the SCN neuronal network plays a critical role in integrating and transducing rhythms of individual oscillators to overt and stable ...

On the Inference of Functional Circadian Networks Using Granger ...

... oscillatory networks ... This is an excellent system for developing algorithms for mapping functional connectivity. ... functional connections in the SCN from gene.

System-level time computation and representation in the ... - Nature

The circadian Ca2+ rhythm, which originates both endogenously from the core loop and exogenously from the SCN neuronal network, is at least ...

Phase Gradients and Anisotropy of the Suprachiasmatic Network

These local differences in phase are distinct from the global phase relationship – that between individual cells and the mean oscillation of the ...

Deciphering clock cell network morphology within the biological ...

One of the key elements governing the spatiotemporal circadian dynamics is the SCN clock cell-to-cell network morphology, which is currently ...

Entrainment within hierarchical circadian oscillator networks

For a network consisting of a single central oscillator coupled to a chain of N feed-forward peripheral oscillators, we introduce a systematic way to derive an ...

Hubs of the small-world network are located in the central SCN. (A ...

... physically nearby neurons, and a second peak corresponding to the distance for functional connections between central SCN regions. For SCN3, these peaks are ...

Network Dynamics Mediate Circadian Clock Plasticity

DNA methylation is necessary to temporally reorga- nize circadian phasing among SCN neurons, which in turn changes the period length of the ...

Functional network inference of the suprachiasmatic nucleus

We show that hubs of this small-world network are preferentially located in the central SCN, with sparsely connected shells surrounding these ...

Coupled network of the circadian clocks: a driving force of rhythmic ...

The molecular clockwork within SCN and non-SCN tissues is nearly identical consisting of the same clock genes and proteins driving oscillations ...

The suprachiasmatic nucleus: Current Biology - Cell Press

Figure 3 SCN networks. ... 10. Moore, R.Y. ... ). (C) False-coloured map of oscillator phases (expressed as phase difference from field mean) from ...

The Suprachiasmatic Nucleus and the Circadian Timekeeping ...

The most striking property of the SCN as a network is the synchronization of the component individual oscillator cells. Synchrony is achieved when the ...

Circadian Synchrony: Sleep, Nutrition, and Physical Activity - Frontiers

The multilevel oscillatory network of the circadian clock provides ample pharmacological targets that include not only the core clock components such as BMAL1, ...