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Mast cell|derived BH4 and serotonin are critical mediators of ...


Mast cell–derived BH4 and serotonin are critical mediators of ...

We found that injury induced the nociceptive neuropeptide substance P, mast cell degranulation, and granule nerve colocalization.

Mast cell-derived BH4 and serotonin are critical mediators ... - PubMed

We found that injury induced the nociceptive neuropeptide substance P, mast cell degranulation, and granule nerve colocalization.

Mast cell-derived BH4 is a critical mediator of postoperative pain

Skin injury induced the nociceptive neuropeptide substance P, which directly triggers the release of BH4-dependent serotonin in mouse and human mast cells.

Mast cell BH4–serotonin metabolic network implicated in ... - Nature

Mast cell-derived BH4 and serotonin are critical mediators of postoperative pain. Sci. Immunol. 9, eadh0545 (2024). Article CAS PubMed Google ...

Mast cell-derived BH4 is a critical mediator of postoperative pain

... BH4-dependent serotonin in mouse and human mast cells. Substance P receptor blockade substantially ameliorated postoperative pain. Our ...

Mast cell-derived BH4 and serotonin are critical mediators of ...

Request PDF | Mast cell-derived BH4 and serotonin are critical mediators of postoperative pain | Postoperative pain affects most patients ...

Mast cell–derived BH4 and serotonin are critical mediators of ...

The nociceptive neuropeptide substance P was detected at tissue injury sites and triggered BH4-dependent serotonin release from mast cells, thus defining ...

(PDF) Mast cell-derived BH4 is a critical mediator of postoperative pain

Skin injury induced the nociceptive neuropeptide substance P, which directly triggers the release of BH4-dependent serotonin in mouse and human ...

Mast cell-derived BH4 is a critical mediator of postoperative pain

Paw serotonin levels of Brn3A-creERT; Gch1 mice, mediator ... recycling arms of the BH4 pathway as well as the serotonin synthesis pathway.

Thomas Köcher on LinkedIn: Mast cell–derived BH4 and serotonin ...

I am happy to share a recent publication where we contributed with quite some mass spectrometric measurements. Nice read! Mast cell–derived BH4 ...

The evolving role of mast cells in wound healing - Wiley Online Library

Platelets release the mediator 5-hydroxyindoleacetic acid, a serotonin ... Mast cell-derived BH4 is a critical mediator of postoperative pain.

IASP on X: "We want to hear from you! Come over to Pain ...

Come over to Pain Researcher and discuss this #PapersoftheWeek #EditorsPick touting mast cell-derived BH4 and serotonin as critical mediators of

Mast cell tetrahydrobiopterin contributes to itch in mice

... BH4 de novo synthesis may become essential for stimulation evoked mediator production in the context of itch.14, 15 Indeed, serotonin ...

Mast Cells | Harvard Catalyst Profiles

Mast cell-derived BH4 and serotonin are critical mediators of postoperative pain. Sci Immunol. 2024 Aug 23; 9(98):eadh0545. View in: PubMed. Granulocytes and ...

Nitric oxide: a major determinant of mast cell phenotype and function

Mast cells (MC) are important in the numerous physiological processes of homeostasis and disease. Most notably, MC are critical effectors in the development ...

Tetrahydrobiopterin, a Critical Factor in the Production and Role of ...

Chair in Asthma Research. 1 The abbreviations used are: MC, mast cell(s); Ag, antigen; IFN-␥, ... acetyl serotonin, we demonstrated that diminishing BH4 leads to ...

Shane JF Cronin - X.com

- how #mastcell -derived #BH4/#serotonin drives ... Mast cell–derived BH4 and serotonin are critical mediators of postoperative pain.

Serotonin | Harvard Catalyst Profiles

... mediator. Descriptor ID. D012701. MeSH Number(s). D02.092.211.215.801 ... Mast cell-derived BH4 and serotonin are critical mediators of postoperative pain.

Mast cells as the strength of the inflammatory process - Termedia

As discussed earlier, infiltration of inflammatory cells and activity of cells already existing at the site of inflammation are crucial for this ...

Chemical Mediators of Inflammation in Animals

Mediators derived from plasma include complement and ... Mast cells, platelets, and basophils produce the vasoactive amines serotonin and histamine.