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Mechanical Stiffness Controls Dendritic Cell Metabolism and Function


Mechanical Stiffness Controls Dendritic Cell Metabolism and Function

Stiffness in the tissue microenvironment changes in most diseases and immunological conditions, but its direct influence on the immune ...

Mechanical Stiffness Controls Dendritic Cell Metabolism and Function

show that environmental stiffness controls dendritic cell metabolism, phenotype, and inflammatory function through downstream Hippo-signaling ...

Mechanical Stiffness Controls Dendritic Cell Metabolism and Function.

Here, we show that static tension impacts immune cell function, maturation, and metabolism. Bone-marrow-derived and/or splenic dendritic cells (DCs) grown in ...

Mechanical Stiffness Controls Dendritic Cell Metabolism and Function

Consistently, DCs grown under higher stiffness show increased activation and flux of major glucose metabolic pathways. In DC models of autoimmune diabetes and ...

GSE162061 - GEO Accession viewer

Title, Mechanical Stiffness Controls Dendritic Cell Metabolism and Function ; Organism, Mus musculus ; Experiment type, Expression profiling by ...

Mechanical Stiffness Controls Dendritic Cell Metabolism and Function

Stiffness in the tissue microenvironment changes in most diseases and immunological conditions, but its direct influence on the immune system is poorly ...

Mechanical Stiffness Controls Dendritic Cell Metabolism and Function

Stiffness in the tissue microenvironment changes in most diseases and immunological conditions, but its direct influence on the immune system is poorly ...

Tuning immunity through tissue mechanotransduction - Nature

Mechanical stiffness controls dendritic cell metabolism and function. Cell Rep. 34, 108609 (2021). This study connects mechanosensing via ...

Mechanosensing in macrophages and dendritic cells in steady-state ...

Immune cell mechanotransduction is an emerging field, where accumulating evidence suggests a role for extracellular physical cues coming from tissue stiffness ...

Dendritic Cell Migration Is Tuned by Mechanical Stiffness of the ...

These data suggest that DC phenotypes and motilities are altered as a function of the mechanical stiffness of their environment. While mature DCs have been the ...

Mechanobiology of myeloid cells - ScienceDirect.com

Tissue-resident myeloid cells sense and transduce mechanical signals such as stiffness, stretch and compression.

Dendritic cell Piezo1 integrating mechanical stiffness and ... - bioRxiv

Dendritic cells (DCs) play an important role in anti-tumor immunity by inducing T cell differentiation. Herein, we found that the mechanical ...

Issue: Cell Reports

Chakraborty et al. show that environmental stiffness controls dendritic cell metabolism, phenotype, and inflammatory function through downstream ...

(PDF) Dendritic Cell Migration Is Tuned by Mechanical Stiffness of ...

Our study provides evidence for a role for environmental mechanical stiffness in the surveillance strategy of immature DCs in tissues.

Mechanical stiffness promotes skin fibrosis through Piezo1 ... - Nature

In particular, in dendritic cells, Piezo1 serves as an important sensor that promotes cell metabolism and inflammatory function under ...

Nemanja Milicevic on X: "RT @Amro_Hussien: Mechanical Stiffness ...

RT @Amro_Hussien: Mechanical Stiffness Controls Dendritic Cell Metabolism and Function | @CellReports ♦ #Mechanical stiffness promotes D…

Tissue stiffness likely drives immune responses in many chronic ...

Citation: Mechanical Stiffness Controls Dendritic Cell Metabolism and Function. DOI: 10.1016/j.celrep.2020.108609. Other collaborators include ...

Metabolic regulation of dendritic cell activation and immune function ...

AAs are involved in various metabolic activities and are crucial for controlling DCs' function. DCs are vulnerable to environmental changes caused by AA ...

Engineering Hydrogels for Modulation of Dendritic Cell Function

Dendritic cells (DCs), the most potent antigen-presenting cells, are necessary for the effective activation of naïve T cells.

Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells ...

... DC mechanical sensor Piezo1 stimulated by mechanical stiffness ... Chakraborty, Mechanical stiffness controls dendritic cell metabolism and function, Cell Reports ...