Mechanical coupling in myosin V

Mechanical coupling in myosin V: a simulation study - PubMed

Myosin motor function depends on the interaction between different domains that transmit information from one part of the molecule to ...

Mechanical Coupling in Myosin V: A Simulation Study - ScienceDirect

The swinging lever arm hypothesis is the most widely accepted model of myosin V function. This model describes a cycle in which the release of ATP hydrolysis ...

A model for the chemomechanical coupling of myosin-V molecular ...

We analytically studied the dynamics of the motor, such as the stepping ratio, dwell time between two mechanical steps, and velocity, under varying force and ...

Myosin V: Chemomechanical-coupling ratchet with load-induced ...

The model allows for branched chemomechanical cycles and takes into account not only two different force-generating mechanical transitions ...

Direct observation of the mechanochemical coupling in myosin-V ...

Mechanical studies at the multiple and single molecule level suggest that there is tight coupling (i.e. one ATP is hydrolyzed per power ...

Mechanochemical model for myosin V - PNAS

Both of these models treat the neck domains as elastic filaments and predict transition rates between quasiequilibrium mechanical and chemical states based on ...

Chemomechanical Coupling and Motor Cycles of Myosin V - MPIKG

For resisting forces that exceed stall, myosin V has been proposed to act as a mechanical ratchet (13): When stepping backward in a forced manner, the stepping ...

Myosin-V is a mechanical ratchet - PNAS

For most of these motors tight coupling of forward motion to ATP hydrolysis has been reported (6, 20, 21). In contrast, the modes of force-induced backward ...

Three myosin V structures delineate essential features of chemo ...

The structural alterations (chemo‐mechanical coupling) in the myosin motor that occur upon actin binding and product release (Pi followed by MgADP) are ...

Mechanical Coupling in Myosin V: A Simulation Study - OUCI

Yildiz, Myosin V walks hand-over-hand: single fluorophore imaging with 1.5 nm localization, Science, № 300, с. · Rief, Myosin-V stepping kinetics: a molecular ...

A model for the chemomechanical coupling of myosin-V molecular ...

... myosin-V exhibits nearly tight chemo-. mechanical coupling under no external force,. 7. can it still retain. the nearly tight coupling under ...

Myosin-V as a Mechanical Sensor: An Elastic Network Study

), full nonlinear EN equations were used, and coordination between conformational changes in two coupled units in the myosin dimer, resulting ...

Myosin V: Chemomechanical-coupling ratchet with load-induced ...

Dive into the research topics of 'Myosin V: Chemomechanical-coupling ratchet with load-induced mechanical slip'. Together they form a unique fingerprint.

Mechanical Coupling in Myosin V: A Simulation Study | Request PDF

Request PDF | Mechanical Coupling in Myosin V: A Simulation Study | Myosin motor function depends on the interaction between different domains that transmit ...

Myosin V: Chemomechanical-coupling ratchet with load-induced ...

Myosin V: Chemomechanical-coupling ratchet with load-induced mechanical slip. https://doi.org/10.1038/s41598-017-13661-0 · Full text. Journal: Scientific ...

Simultaneous Measurement of Nucleotide Occupancy and ...

Simultaneous Measurement of Nucleotide Occupancy and Mechanical Displacement in Myosin-V, a Processive Molecular Motor ... Figure 2 Chemo-mechanical coupling in ...

Visualization of the mechanochemical coupling in myosin V using ...

... Myosin 5a · Mihály Kovács. downloadDownload free PDF View PDFchevron_right · Watching the walk: Observing chemo‐mechanical coupling in a processive myosin motor.

Mechanical Coupling between Myosin Molecules Causes ...

actin for a shorter time than t1; and V > 1 so that myosin- myosin interactions in an ensemble accelerate actin sliding speed (these results remain true ...

Examining the Coupling of the Mechanical and Chemical Functions ...

... Myosin Ib (myo1b) is single-headed and may link the cell membrane to the actin network acting as a tension sensor; while myosin V (myoV) is double-headed ...

Chemomechanical coupling and motor cycles of myosin V

The binding of an ATP molecule to the rear head leads to the TD state, which, through weakening of the actomyosin bond, is followed by a mechanical step. This ...