Mechanism and Regulation of DNA|Protein Crosslink Repair by the ...

Mechanisms and Regulation of DNA-Protein Crosslink Repair ...

DNA-protein crosslinks (DPCs) are deleterious DNA lesions that occur when proteins are covalently crosslinked to the DNA by the action of ...

Mechanisms and Regulation of DNA-Protein Crosslink Repair ...

DNA-protein crosslinks (DPCs) are deleterious DNA lesions that occur when proteins are covalently crosslinked to the DNA by the action of ...

Mechanism and Regulation of DNA-Protein Crosslink Repair by the ...

SPRTN accomplishes DPC processing through a unique DNA-induced protease activity, which is controlled by several sophisticated regulatory mechanisms.

Mechanism and Regulation of DNA-Protein Crosslink Repair by the ...

Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN.-article.

Mechanism and Regulation of DNA-Protein Crosslink Repair by the ...

Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN ; Julian Stingele ; Roberto Bellelli.

Mechanism and Regulation of DNA-Protein Crosslink Repair by the ...

Covalent DNA-protein crosslinks (DPCs) are toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription.

Mechanism and Regulation of DNA-Protein Crosslink Repair by the ...

Title: Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN ... Stingele, Julian; Bellelli, Roberto ...

Mechanisms of DNA−protein cross-link formation and repair

DNA-protein cross-links (DPCs) are bulky, ubiquitous, and toxic. · DPCs block DNA replication and transcription. · DPCs are degraded by proteasome and/or DPC ...

DNA–protein cross-link repair: what do we know now?

The nuclease-dependent DPC repair mechanisms targeting DNA molecules are restricted by the accessibility of nucleases to substrates. Large ...

Editorial: The repair of DNA–protein crosslinks - Frontiers

DNA–protein crosslinks (DPCs) are among the most ubiquitous and heterogenous lesions that arise from the covalent linking of a protein with a ...

Mechanism and function of DNA replication‐independent DNA ...

DNA‐protein crosslinks (DPCs) obstruct essential DNA transactions, posing a serious threat to genome stability and functionality.

New insights into the regulation of DNA-Protein Crosslink Repair by ...

Proteins that are covalently bound to DNA form a specific type of DNA lesion known as DNA–Protein Crosslinks (DPCs). DPCs represent physical obstacles to ...

Mechanisms of DNA–protein crosslink repair - Semantic Scholar

205 Citations · Enzymatic Processing of DNA–Protein Crosslinks · Mechanisms and Regulation of DNA-Protein Crosslink Repair During DNA Replication by SPRTN ...

Transcription-coupled DNA–protein crosslink repair by CSB ... - Nature

DNA–protein crosslinks (DPCs) arise from enzymatic intermediates, metabolism or chemicals like chemotherapeutics. DPCs are highly cytotoxic ...

Mechanisms of DNA−protein cross-link formation and repair

Download Citation | Mechanisms of DNA−protein cross-link formation and repair | Covalent binding of DNA to proteins produces DNA−protein cross-links (DPCs).

Mechanisms and Regulation of DNA-Protein Crosslink Repair ...

DNA-protein crosslinks (DPCs) are deleterious DNA lesions that occur when proteins are covalently crosslinked to the DNA by the action of variety of agents ...

DNA–protein crosslink proteases in genome stability - Nature

Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are common and bulky DNA lesions that interfere with DNA ...

Ubiquitin signaling and the proteasome drive human DNA–protein ...

Enhanced DNA repair capability represents a potential avenue through which cancer cells become resistant towards DNA–protein crosslink (DPC) ...

Mechanisms and Regulation of DNA-Protein Crosslink Repair ...

Mechanisms and Regulation of DNA-Protein Crosslink Repair During DNA Replication by SPRTN Protease. Front. Mol. Biosci. Pub Date : 2022-06-15

Mechanisms and Regulation of DNA-Protein Crosslink Repair ...

DNA-protein crosslinks (DPCs) are deleterious DNA lesions that occur when proteins are covalently crosslinked to the DNA by the action of variety of agents ...