Mechanisms and Management of Immune Checkpoint Inhibitor ...

Inhibition of suppressive factors called “immune checkpoints” accelerates activated T-cell to invade and injure tumor cells but may also allow ...

Mechanisms of immune checkpoint inhibitors - Nature

Immune checkpoints are a type of immunosuppressive molecules expressed on immune cells, which can regulate the degree of immune activation and ...

Overview of Checkpoint Inhibitors Mechanism of Action

Checkpoint blockade using ICIs overcomes this tumor-mediated immune inhibition, leading to a proinflammatory tumor microenvironment which ...

Immune Checkpoint Inhibitors - NCI

Immunotherapy drugs called immune checkpoint inhibitors work by blocking checkpoint proteins from binding with their partner proteins.

Immune Checkpoint Inhibitors: Fundamental Mechanisms, Current ...

Immune checkpoint pathways are activated when co-inhibitory molecules on the surface of cancer cells or antigen-presenting cells (APCs) bind to T-cell surface ...

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

Immune checkpoint blockade inhibits T cell–negative costimulation in order to unleash antitumor T-cell responses that recognize tumor antigens. Importantly, the ...

Review Immune mechanisms of toxicity from checkpoint inhibitors

Immunotherapy has changed the treatment landscape for cancer over the past decade. Inhibitors of the immune checkpoint proteins cytotoxic T lymphocyte ...

These toxicities range from hypersensitivity to expansion of existing T cell effectors to antibody responses or priming of a de novo immune ...

Mechanisms of action and rationale for the use of checkpoint ...

During T cell activation, inhibitory receptors such as CTLA-4, PD-1, Lag-3, Tim-3, Tigit and Vista are also induced to limit overstimulation of the immune ...

Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical ...

Immune checkpoint inhibitors (ICIs) have made an indelible mark in the field of cancer immunotherapy. Starting with the approval of ...

Mechanisms of immune-related adverse events during the treatment ...

Immune checkpoint inhibitors are novel biologic agents to treat cancer by inhibiting the regulatory interactions that limit T cell cytotoxicity to tumours.

Mechanisms of Immune Checkpoint Inhibitor-Mediated Colitis

However, the density of Tregs in the tumor increased upon anti-CTLA-4 treatment in most cancer types studied (13). Increased levels of Tregs are also observed ...

Mechanisms of Resistance to Immune Checkpoint Blockade

The tumor microenvironment, tumor immunogenicity, antigen presentation, and classic oncologic pathways play roles in response and resistance to immune ...

Evolving insights into the mechanisms of toxicity associated with ...

Immune checkpoint inhibitors (ICIs) are a novel form of cancer treatment that unleash host immune responses to attack the neoplasm. There are ...

A narrative review of immune checkpoint mechanisms and current ...

The primary mechanism is believed to involve direct competition of CTLA-4 with CD28 for binding to CD80/86 (27). This mainly occurs in tumour-draining lymph ...

Immune Checkpoint Inhibitors - MD Anderson Cancer Center

Immune checkpoint inhibitors stop the immune system from turning off before cancer is completely eliminated. They're a type of immunotherapy.

Management of Immune-Related Adverse Events in Patients ...

Immune checkpoint inhibitors (ICPis) targeting cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4), programmed cell death-1 (PD-1), and PD ligand 1 (PD-L1) ...

Mechanism‐based treatment of cancer with immune checkpoint ...

Over the past decade, antagonistic antibodies known as immune checkpoint inhibitors have become a new pillar of cancer treatment and have ...

Molecular Mechanisms of Resistance to Immune Checkpoint ... - MDPI

Over the past decade, immune checkpoint inhibitors (ICI) have revolutionized the treatment of advanced melanoma and ensured significant improvement in overall ...

Immune-Checkpoint Inhibitors-Induced Type 1 Diabetes Mellitus

Immunotherapy using immune-checkpoint inhibitors (ICIs) has improved cancer management and has become a cornerstone of cancer treatment over the ...