Mechanisms and consequences of endothelial cell senescence

We now understand that senescent endothelial cells are highly active, secretory and pro-inflammatory, and have an aberrant morphological phenotype.

Mechanisms and consequences of endothelial cell senescence - PMC

Senescent endothelial cells are highly active, secretory and pro-inflammatory, and exhibit an aberrant morphological phenotype.

(PDF) Mechanisms and consequences of endothelial cell senescence

Endothelial cell telomere dysfunction induces senescence and results in vascular and metabolic impai... ... In advanced age, increases in ...

Mechanisms and consequences of endothelial cell senescence

The vascular endothelium is particularly susceptible to pathogenic stimuli that activate tumour suppressor pathways leading to cellular senescence. We now ...

Endothelial senescence in vascular diseases - Nature

Various key features of endothelial senescence enhance susceptibility to the development of CVDs, where reduced capacity for replication and NO ...

Endothelial cell senescence — understanding aging and disease

The phenotypic hallmarks of cellular senescence are a permanent halt in the cell cycle, an enlarged cell morphology, an active metabolic state, and a switch to ...

Endothelial Senescence: From Macro- to Micro-Vasculature and Its ...

Figure 1. Mechanism of endothelial cell senescence. Senescent endothelial cells develop a senescence-associated secretory phenotype (SASP) and an increase of SA ...

Senescence of endothelial cells promotes phenotypic changes in ...

The aim of this study was to characterize oxidative stress-induced endothelial cells senescence and identify their paracrine effects on the primary cell type ...

Mechanisms and consequences of endothelial cell senescence

Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial ...

Endothelial cell dysfunction and senescence: biologic mechanisms ...

Senescence in ECs promotes vascular remodeling, and evidence indicates that EC senescence has a pathogenic role in atherosclerosis, heart failure, and obesity.

Endothelial cellular senescence is inhibited by nitric oxide - PNAS

Taken together, the present data provide evidence demonstrating an NO-dependent mechanism in the delay of endothelial cell senescence. Consequently, the ...

The role of mitofusin 2 in regulating endothelial cell senescence

In human endothelial cells, Ang II reduced MFN2 expression while increasing senescence markers P21 and P53. siMFN2 treatment worsened Ang II-induced senescence, ...

Vascular endothelial senescence: from mechanisms to ...

As a direct consequence of the permanent growth arrest, endothelial cell senescence may impair the repair capacity of the endothelial lining (24). In this ...

Mechanisms and consequences of endothelial cell senescence

Mechanisms and consequences of endothelial cell senescence. ; Bloom, Samuel I. ; Islam, Md Torikul ; Lesniewski, Lisa A. ; Donato ...

Mechanical Fingerprint of Senescence in Endothelial Cells

Endothelial senescence entails alterations of the healthy cell phenotype, which accumulate over time and contribute to cardiovascular ...

Mechanisms of endothelial senescence - The Physiological Society

When endothelial cells from different vascular beds are grown in culture they show a limited capacity to divide, eventually entering into a ...

Vascular endothelial senescence: from mechanisms to ...

The endothelial senescent phenotype and its pathophysiological consequences. Review. 329. ENDOTHELIAL CELL SENESCENCE ... Cellular and molecular mechanisms ...

Endothelial Cell Senescence | Request PDF - ResearchGate

One such process is cellular senescence. In endothelial cells the senescent phenotype can be induced by a number of factors, including telomere damage, ...

Factors and Pathways Modulating Endothelial Cell Senescence in ...

Figure 2. Molecular mechanism mediating endothelial cell senescence and vascular aging. SIRT1 protects against endothelial dysfunction by ...

Vascular Endothelial Senescence: Pathobiological Insights ...

Cellular senescence is a stable form of cell cycle arrest in response to various stressors. While it serves as an endogenous pro-resolving mechanism, ...