Mechanisms controlling pancreatic islet cell function in insulin ...

The secretion of these hormones from pancreatic β-cells and α-cells, respectively, is controlled by metabolic, endocrine, and paracrine regulatory mechanisms.

Metabolic homeostasis in mammals is tightly regulated by the complementary actions of insulin and glucagon. The secretion of these hormones from pancreatic ...

Mechanisms controlling pancreatic islet cell function in insulin ...

Advances provide a new perspective for the understanding of the β-cell failure that triggers type 2 diabetes, and highlight the importance of ...

Peeling the onion: another layer in the regulation of insulin secretion

The pancreatic islet is a mini-organ, and paracrine signaling between β cells and other islet cells plays an important role in modulating GSIS ( ...

Mechanisms of the Amplifying Pathway of Insulin Secretion in the β ...

Pancreatic islet β cells secrete insulin in response to nutrient secretagogues, like glucose, dependent on calcium influx and nutrient metabolism.

Physiology of pancreatic β-cells: Ion channels and molecular ...

Hormonal secretion of the pancreatic islet is highly regulated, as there are paracrine relationships between the different cell types of the islet that ...

Pancreas Islet Cell Function - an overview | ScienceDirect Topics

Here, the brain uses a principle called feed-forward control in which the brain sends signals to the pancreatic islet before changes in blood glucose levels ...

Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 ...

IL-1β and/or TNF-α plus IFN-γ induce β-cell apoptosis via the activation of β-cell gene networks under the control of the transcription factors NF-κB and STAT-1 ...

Mechanisms controlling pancreatic islet cell function in insulin ...

Publications that cite this publication · The Role of Palmitoleic Acid in Regulating Hepatic Gluconeogenesis through SIRT3 in Obese Mice · Liver-derived ...

Pancreatic Islet Adaptation and Failure in Obesity and Diabetes

Acetylcholine , the neurotransmitter of the parasympathetic nervous system, plays a key role in the regulation of insulin secretion in pancreatic islet β-cells ...

Optogenetics in Pancreatic Islets: Actuators and Effects | Diabetes

Insulin is natively expressed from the INS locus on human chromosome 11 under the control of the highly β-cell–specific insulin promoter. It is ...

Reversible changes in pancreatic islet structure and function ...

When KATP channels are open, as at low plasma glucose levels, Ca2+ influx and insulin secretion are prevented, switching off insulin release. A ...

Pancreatic Beta-cell Dysfunction in Type 2 Diabetes - Sage Journals

Pancreatic β-cells produce and secrete insulin to maintain blood glucose levels within a narrow range. Defects in the function and mass of ...

Insulin receptors in β-cells are critical for islet compensatory ... - PNAS

Insulin and insulin-like growth factor 1 (IGF1) are ubiquitous growth factors that regulate proliferation in most mammalian tissues including pancreatic ...

Nutrient Regulation of Pancreatic Islet β-Cell Secretory Capacity and ...

Pancreatic islet β-cells exhibit tremendous plasticity for secretory adaptations that coordinate insulin production and release with nutritional demands.

Secretion of Insulin in Response to Diet and Hormones

Each pancreatic islet is composed of α, β, d, ε and PP (F) cells; these are primarily endocrine (hormone-secreting) cells, containing numerous secretory ...

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice ...

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only hormone capable of lowering the blood glucose concentration.

Pancreatic islet-autonomous insulin and smoothened-mediated ...

The mechanisms controlling this insulin expression are unknown. We have previously shown that in α -cells, inhibition of the transcription factor Arx and the.

Islet Biology During COVID-19: Progress and Perspectives

Although the regulation of insulin secretion from beta cells in response to nutrient intake has been studied for decades, new molecular clues ...

Controlling Insulin Secretion: An Exciting TASK - Oxford Academic

The β-cells of the pancreatic islets of Langerhans secrete insulin in response to metabolic fuels and neurohormonal inputs after a meal. The proper regulat.