Mechanisms of NLRP3 inflammasome activation and the ...

This review begins by providing a comprehensive summary of recent research progress regarding the mechanisms governing NLRP3 inflammasome activation.

Mechanism of NLRP3 inflammasome activation - PubMed

Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from ...

The NLRP3 Inflammasome: An Overview of Mechanisms of ...

The NLRP3 inflammasome is activated by diverse stimuli, and multiple molecular and cellular events, including ionic flux, mitochondrial ...

An update on the regulatory mechanisms of NLRP3 inflammasome ...

It is generally accepted that NLRP3 inflammasome activation is regulated through a two-step process, with priming at the transcriptional and ...

Molecular mechanisms regulating NLRP3 inflammasome activation

In this review, we summarize the current understanding of the mechanisms by which the NLRP3 inflammasome is activated in the cytosol.

Structural Mechanisms of NLRP3 Inflammasome Assembly and ...

... inflammasome. We further implicate structure-derived mechanisms for the assembly and activation of the NLRP3 inflammasome.

The mechanism of NLRP3 inflammasome activation and its ...

The review summarizes the latest advances in the mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors.

Mechanism of NLRP3 inflammasome activation and its role in ...

This review aimed to clarify the structure and activating mechanism of NLRP3 inflammasome and its key role in the pathogenesis of AD

The NLRP3 Inflammasome Pathway: A Review of Mechanisms and ...

Upon activation by PAMPs and DAMPs, NLRP3 oligomerizes and activates caspase-1 which initiates the processing and release of pro-inflammatory cytokines IL-1β ...

The Mechanism of the NLRP3 Inflammasome Activation and ...

This review discusses the basic mechanism of NLRP3 inflammasome activation and the IL-1-induced inflammatory cascade and explains the NLRP3 inflammasome- ...

Mechanism of NLRP3 inflammasome activation - Sutterwala - 2014

This review highlights our current understanding of the mechanisms of both priming and activation of the NLRP3 inflammasome.

Mechanism and Regulation of NLRP3 Inflammasome Activation

The NLRP3 inflammasome is an essential mediator of host immune responses through the activation of caspase-1 and interleukin 1 beta (IL-1β)/IL-18.

Mechanisms of NLRP3 Inflammasome Activation: Its Role in the ...

This result suggests that the NLRP3 inflammasome may be an appropriate target for reducing neuroinflammation and alleviating pathological processes in AD.

New Insights on NLRP3 Inflammasome: Mechanisms of Activation ...

This review gives an overview of the established NLRP3 inflammasome assembly, its brief molecular mechanistic activations as well as a current update on ...

The NLRP3 inflammasome: Mechanisms of activation, regulation ...

The NLRP3 inflammasome is activated by a variety of stimuli, and several molecular and cellular events, such as ion influx, mitochondrial dysfunction, reactive ...

Recent advances in the mechanisms of NLRP3 inflammasome ...

Current understanding of the regulatory mechanisms of NLRP3 inflammasome activation as well as inhibitors that specifically and directly targetNLRP3 are ...

Mechanism and Regulation of NLRP3 Inflammasome Activation

The NLRP3 inflammasome is an essential mediator of host immune responses through the activation of caspase-1 and interleukin 1 beta (IL-. 1β)/IL-18. The NLRP3 ...

Mechanisms of NLRP3 inflammasome activation. Decreases in ...

dsRNA, increased intracellular Ca²⁺ levels, K⁺ outflow, increased ROS and other cellular stress factors activate PKR, and PKR activates the NLRP3 inflammasome.

Mechanisms of inflammasome activation and regulation | Journal of ...

It was hypothesized that this cell cycle–mediated restriction of NLRP3 activation is caused by the limited cellular concentration of NEK7, such ...

[PDF] The NLRP3 Inflammasome: An Overview of Mechanisms of ...

Current understanding of the mechanisms ofNLRP3 inflammasome activation by multiple signaling events, and its regulation by post-translational modifications ...