Mechanisms of egfr Gene Transcription Modulation

Mechanisms of egfr gene transcription modulation - PubMed

The epidermal growth factor receptor (EGFR) plays a crucial role in growth, differentiation, and motility of normal as well as cancer cells.

Mechanisms of egfr Gene Transcription Modulation - AACR Journals

The assessment of the CA SSR I number of CA dinucleotide repeats and other egfr polymorphisms as predictors for therapy response and clinical outcome is very ...

Modulation of epidermal growth factor receptor gene transcription by ...

The influence of a highly polymorphic CA dinucleotide repeat in the epidermal growth factor receptor (EGFR) gene on transcription was ...

Modulation of Epidermal Growth Factor Receptor Gene ...

Transcription of the EGFR gene starts at multiple initiation sites within the GC-rich promoter that lacks a TATA or CAAT box (8). It has been shown that the ...

Correction: Article on Mechanisms of egfr Gene Transcription

In the article on mechanisms of egfr gene transcription modulation in the December 15, 2006 issue of Clinical Cancer Research, ...

Modulation of EGFR gene transcription by secondary structures, a ...

On this clinical background, understanding novel transcriptional regulation mechanisms that regulate EGFR proto-oncogene expression is important. Moreover ...

Transcriptomic and ChIP-sequence interrogation of EGFR signaling ...

AC2 contains 175 transcripts, whose activation peaked 2 h post EGF treatment, and these genes are known as transcriptional repressors (Fig. 2a, ...

EGFR in Cancer: Signaling Mechanisms, Drugs, and Acquired ...

Culminating the EGF-stimulated gene expression program, late-response genes display persistent up- (delayed upregulated genes, DUGs) or down-regulation (DDGs), ...

Control of cell metabolism by the epidermal growth factor receptor

Here we review the mechanisms by which EGFR regulates cell metabolism, including by modulation of gene expression and protein function.

Modulation of EGFR Gene Transcription by a Polymorphic ...

Therefore, it is crucial to know how the expression lev- els of c-erbB genes are controlled. Besides, post-trans- lational mechanisms, alteration of gene copy ...

Mechanisms of the regulation of EGF receptor gene expression by ...

These studies demonstrate that the calciotropic hormones PTH and calcitriol increase EGF receptor expression by different mechanisms. The former increases EGFR ...

EGFRvIII gene rearrangement is an early event in glioblastoma ...

Epigenetic mechanisms had a role in maintaining heterogeneous EGFRvIII expression. Demethylation induced a 20–60% increase in the percentage of ...

Mechanisms ofegfrGene Transcription Modulation ... - OUCI

AbstractThe epidermal growth factor receptor (EGFR) plays a crucial role in growth, differentiation, and motility of normal as well as cancer cells.

Modulation of EGFR Gene Transcription by a Polymorphic ...

The epidermal growth factor receptor (EGFR) plays a crucial role in growth, differentiation and motility of normal as well as tumor cells.

Gene expression signatures modulated by epidermal growth factor ...

Aberrant activation of signaling pathways downstream of epidermal growth factor receptor (EGFR) has been hypothesized to be one of the ...

Genomic and biological study of fusion genes as resistance ... - Nature

The clinical significance of gene fusions detected by DNA-based next generation sequencing remains unclear as resistance mechanisms to EGFR ...

Mutations in the EGFR Pathway | myadlm.org

Mutations in the gene encoding EGFR that lead to overexpression of the protein have been associated with a number of different cancers.

Mechanism of action of EGFR mutations - Thorax BMJ

The role of mutant epidermal growth factor receptor (EGFR) kinases in the growth of a host of human cancers including lung cancer is well known. The activation ...

Mechanism for activation of mutated epidermal growth factor ... - PNAS

The gene encoding the epidermal growth factor receptor (EGFR) tyrosine kinase is somatically mutated in a substantial fraction of patients with lung cancer.

Molecular mechanisms of curcumin action: Gene expression

WT-1 gene encodes a transcription factor and modulates cell growth and differentiation. WT-1 gene is highly expressed in leukemia and various ...