Mechanisms of immune checkpoint inhibitors

Mechanisms of immune checkpoint inhibitors - Nature

In this review, we systematically summarize the current status of immune checkpoints in cancer and the existing regulatory roles of circRNAs on immune ...

Overview of Checkpoint Inhibitors Mechanism of Action

Several mechanisms are hypothesized as possible contributors in the development of immune-mediated effects. Autoantibodies, T-cell infiltration, ...

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

This review provides an overview of immune checkpoint blockade therapy from a basic biology and immunologic perspective for the cancer research community.

Immune Checkpoint Inhibitors - NCI

Immunotherapy drugs called immune checkpoint inhibitors work by blocking checkpoint proteins from binding with their partner proteins.

Mechanisms of action and rationale for the use of checkpoint ...

During T cell activation, inhibitory receptors such as CTLA-4, PD-1, Lag-3, Tim-3, Tigit and Vista are also induced to limit overstimulation of the immune ...

Mechanisms of resistance to immune checkpoint inhibitors - PMC

There are various resistance mechanisms, such as insufficient antigen recognition by T cells, impaired T‐cell migration and/or infiltration, and reduced T‐cell ...

Immune Checkpoint Inhibitors: Fundamental Mechanisms, Current ...

Immune checkpoint inhibitors (ICI) are a promising form of immunotherapy that have significantly changed the therapeutic landscape for many advanced cancers ...

A narrative review of immune checkpoint mechanisms and current ...

ICIs inhibit the overactivation of immune-checkpoint signalling pathways to a certain extent, thus promoting the immune response. ICIs have achieved prominent ...

Immune mechanisms of toxicity from checkpoint inhibitors - Cell Press

In this review, we discuss our current understanding of the inflammatory toxicities from immune checkpoint inhibitors (ICIs) and propose optimal treatment ...

Mechanisms of immune-related adverse events during the treatment ...

Immune checkpoint inhibitors are novel biologic agents to treat cancer by inhibiting the regulatory interactions that limit T cell cytotoxicity to tumours.

Mechanisms of resistance to immune checkpoint inhibitors - Nature

Here we review the emerging clinical and pre-clinical data identifying novel mechanisms of innate and acquired resistance to immune checkpoint inhibition.

A Highlight of the Mechanisms of Immune Checkpoint Blocker ...

Immunosuppressive metabolites in TME can inhibit anti-tumor immunity, which is attributable to inhibition of immune cell infiltration. Metabolic disorders of ...

Mechanisms of Resistance to Immune Checkpoint Blockade

The tumor microenvironment, tumor immunogenicity, antigen presentation, and classic oncologic pathways play roles in response and resistance to ...

Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical ...

Immune checkpoint inhibitors (ICIs) have made an indelible mark in the field of cancer immunotherapy. Starting with the approval of ...

Mechanisms of tumor resistance to immune checkpoint blockade ...

Here, we focused on the changes in the biological functions of CD8 + T cells to elucidate the underlying resistance mechanisms of ICB therapies.

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer

Here, we review how a range of cancer-cell-autonomous cues, tumor-microenvironmental factors, and host-related influences might account for the heterogeneous ...

Immune Checkpoint Inhibitors and Their Side Effects

Immune checkpoint inhibitors, like PD-1 or PD-L1 inhibitors, are treatments that help the immune system recognize and attack cancer cells.

Cancer immunotherapy with immune checkpoint inhibitors (ICIs)

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies (mAbs) that target inhibitory checkpoint molecules expressed by cell membrane of ...

Immune Checkpoint Inhibitors - MD Anderson Cancer Center

Immune checkpoint inhibitors stop the immune system from turning off before cancer is completely eliminated. They're a type of immunotherapy.

Checkpoint inhibitors | Types of immunotherapy | Cancer Research UK

Drugs that block checkpoint proteins are called checkpoint inhibitors. They stop the proteins on the cancer cells or T cells from pushing the stop button. This ...